{"id":"W4388007017","doi":"10.1016/j.chom.2023.10.002","title":"Unbiased discovery of natural sequence variants that influence fungal virulence","year":2023,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Government of Canada","keywords":"Biology; Virulence; Genetics; Gene; Whole genome sequencing; Genome; Locus (genetics); Cryptococcus neoformans; Sequence analysis; DNA sequencing; Bulked segregant analysis; Computational biology; Gene mapping; Chromosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007107517,0.0003261089,0.0004449819,0.0004693551,0.0003394374,0.0006317409,0.00036816,0.0007131987,0.001547371],"category_scores_gemma":[0.001767747,0.0002436746,0.0003103885,0.0003904352,0.0003251168,0.0001933737,0.0004710938,0.0009116408,0.0004308053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002962775,"about_ca_system_score_gemma":0.000413607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004827165,"about_ca_topic_score_gemma":0.002259725,"domain_scores_codex":[0.9993885,0.000139088,0.00002989511,0.000132952,0.0002139552,0.00009558928],"domain_scores_gemma":[0.999385,0.0002635493,0.0001248411,0.00009453786,0.00007006288,0.00006197526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000855044,0.0002052583,0.02802638,0.0001545549,0.0002647265,0.0008550953,0.0001004998,0.002554806,0.9236855,0.003014473,0.001344751,0.03893891],"study_design_scores_gemma":[0.0004739096,0.002436824,0.1402687,0.0001453454,0.001190166,0.006791382,0.0004021094,0.03845798,0.7636671,0.006268758,0.03973636,0.0001613816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9757379,0.001997339,0.01611212,0.0003996316,0.0001720822,0.0001019898,0.001868884,0.0002529042,0.003357211],"genre_scores_gemma":[0.9876615,0.0008156322,0.008205443,0.0004628561,0.00005990303,0.00004914906,0.001558307,0.00007542088,0.001111822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001547371,"threshold_uncertainty_score":0.005176485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02373948978747237,"score_gpt":0.2774674023494771,"score_spread":0.2537279125620047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}