{"id":"W4388007017","doi":"10.1016/j.chom.2023.10.002","title":"Unbiased discovery of natural sequence variants that influence fungal virulence","year":2023,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Government of Canada","keywords":"Biology; Virulence; Genetics; Gene; Whole genome sequencing; Genome; Locus (genetics); Cryptococcus neoformans; Sequence analysis; DNA sequencing; Bulked segregant analysis; Computational biology; Gene mapping; Chromosome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001429784,0.0001705084,0.000297076,0.0001312348,0.0001295229,0.00002707197,0.0001213174,0.00006909334,0.00003088442],"category_scores_gemma":[0.00009837106,0.0001413719,0.0001126131,0.0005683773,0.000210323,0.0002370824,0.0001313206,0.0002407727,0.0001931389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005689387,"about_ca_system_score_gemma":0.0000947931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002738751,"about_ca_topic_score_gemma":0.00002283728,"domain_scores_codex":[0.9989661,0.00002869178,0.0002286438,0.0002912935,0.0001756444,0.0003096187],"domain_scores_gemma":[0.9992696,0.0001291946,0.00009678313,0.0003238296,0.000121388,0.00005919483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005353203,0.00007060565,0.04566704,0.0001821439,0.00003324911,0.00009173165,0.0003059596,0.00001905723,0.9516072,0.00004383273,0.001785899,0.0001397787],"study_design_scores_gemma":[0.0007838616,0.0001975221,0.4980881,0.000343275,0.00008017573,0.00008327294,0.0003968363,0.000138009,0.4982005,0.00002776281,0.001436291,0.0002244647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964157,0.0009232032,0.00003621067,0.0002040243,0.0004208128,0.0002155823,0.00007612239,0.00009759726,0.001610773],"genre_scores_gemma":[0.9945285,0.0005791307,0.0001710544,0.0003157191,0.00004752036,0.00001135214,0.0000245234,0.00001826432,0.004303875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4534067,"threshold_uncertainty_score":0.576498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02373948978747237,"score_gpt":0.2774674023494771,"score_spread":0.2537279125620047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}