{"id":"W4388011859","doi":"10.1016/j.omtn.2023.102066","title":"Progress and harmonization of gene editing to treat human diseases: Proceeding of COST Action CA21113 GenE-HumDi","year":2023,"lang":"en","type":"review","venue":"Molecular Therapy — Nucleic Acids","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"European Regional Development Fund; Novo Nordisk Fonden; Consejería de Salud y Consumo, Junta de Andalucía; Junta de Andalucía; Lundbeckfonden; Consejería de Transformación Económica, Industria, Conocimiento y Universidades; Consejería de Salud y Familias, Junta de Andalucía; Steno Diabetes Center Aarhus; European Cooperation in Science and Technology","keywords":"Harmonization; Genome editing; Action (physics); Business; Engineering ethics; Knowledge management; Political science; Biotechnology; Genome; Computer science; Gene; Biology; Engineering; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005325889,0.000947931,0.00108661,0.002042048,0.0003732378,0.001719161,0.001279481,0.002397902,0.004892319],"category_scores_gemma":[0.002314113,0.00025977,0.001039958,0.0020541,0.000637529,0.001285855,0.001613922,0.002546012,0.002303434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002720339,"about_ca_system_score_gemma":0.009137162,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005363815,"about_ca_topic_score_gemma":0.005742433,"domain_scores_codex":[0.9989833,0.0002198577,0.00009789867,0.0001118334,0.0004105627,0.0001764665],"domain_scores_gemma":[0.9986719,0.0003602657,0.0001371549,0.00004722532,0.0005602872,0.0002232746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003121374,0.0002654595,0.00013737,0.00980894,0.000108788,0.0002724791,0.0001047606,0.0005720601,0.004254682,0.02280403,0.2378892,0.7234702],"study_design_scores_gemma":[0.00004253525,0.00008826311,0.0003913429,0.0008950419,0.00003243932,0.0002025516,0.00001857969,0.00005082299,0.001166622,0.0006760065,0.996425,0.00001081355],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007537624,0.9691845,0.001770266,0.006796636,0.004000924,0.0002204201,0.0003563201,0.00008094055,0.01683614],"genre_scores_gemma":[0.006254252,0.9569276,0.005972276,0.009147721,0.001266786,0.0003953855,0.001504483,0.00006256215,0.01846893],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005363815,"threshold_uncertainty_score":0.02816629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03568538218232281,"score_gpt":0.3714595403355327,"score_spread":0.3357741581532099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}