{"id":"W4388015891","doi":"10.1002/cnr2.1922","title":"Targeting androgen receptor (<scp>AR</scp>) with a synthetic peptide increases apoptosis in triple negative breast cancer and <scp>AR</scp>‐expressing prostate cancer cell lines","year":2023,"lang":"en","type":"article","venue":"Cancer Reports","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"LNCaP; Androgen receptor; Prostate cancer; Apoptosis; Dihydrotestosterone; Cancer research; Cancer cell; Triple-negative breast cancer; Peptide; Transactivation; Chemistry; Receptor; Cancer; Breast cancer; Endocrinology; Biology; Molecular biology; Internal medicine; Androgen; Medicine; Biochemistry; Gene expression; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001320819,0.0002284609,0.0001748368,0.0001553917,0.00008936996,0.000193898,0.0001157504,0.0001880088,0.001248815],"category_scores_gemma":[0.000105904,0.00007497738,0.0001581568,0.0001324638,0.0001667381,0.0001314242,0.00008277304,0.0004094539,0.0002129105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001490696,"about_ca_system_score_gemma":0.0001898439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003072511,"about_ca_topic_score_gemma":0.00061773,"domain_scores_codex":[0.9998965,0.00001655456,0.000009803,0.00001584676,0.00003959801,0.00002168809],"domain_scores_gemma":[0.999908,0.00002776093,0.00002207188,0.000006458657,0.00001117817,0.00002457499],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001191269,0.0000599897,0.0001344906,0.00004851892,0.000006494799,0.00004167143,0.00001144395,0.00005662847,0.9980038,0.00003664014,0.0000408465,0.001440408],"study_design_scores_gemma":[0.00004354745,0.001736255,0.003338876,0.000007791501,0.00002690075,0.0005363275,0.00002622102,0.0004027488,0.9924555,0.0000191382,0.001402737,0.000003923044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959586,0.001901665,0.0008405223,0.00005709999,0.00003080684,0.00001853186,0.00009218773,0.00002632017,0.001074237],"genre_scores_gemma":[0.9958478,0.001175145,0.001211577,0.00005196274,0.00001634535,0.00002255832,0.0002749519,0.000007538039,0.001392035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001248815,"threshold_uncertainty_score":0.00417769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01704217243019931,"score_gpt":0.2897623010575832,"score_spread":0.2727201286273839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}