{"id":"W4388015997","doi":"10.2139/ssrn.4613653","title":"The Interferon-Inducible Genes IFIT1 and IFIT3 are Essential for Clioquinol-Induced Pyroptosis in Myeloma and Leukemia Cells by Promoting N-Terminal GSDME Translocalization to Mitochondria","year":2023,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Pneumocystis jirovecii pneumonia detection and treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Pyroptosis; Gene; Leukemia; Cancer research; Clioquinol; Mitochondrion; Terminal (telecommunication); Biology; Chemistry; Genetics; Apoptosis; Pharmacology; Programmed cell death; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001782737,0.0002493019,0.0002755351,0.0001778691,0.0002129237,0.0003939586,0.0001388187,0.00047489,0.003513439],"category_scores_gemma":[0.0002637174,0.0001408423,0.0003219628,0.0001402652,0.0002315058,0.0002066685,0.0002667936,0.0006519858,0.001014455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004752489,"about_ca_system_score_gemma":0.000235884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004812098,"about_ca_topic_score_gemma":0.0004859054,"domain_scores_codex":[0.9998221,0.000024646,0.00001438834,0.00003580143,0.00004664526,0.00005653515],"domain_scores_gemma":[0.9998584,0.00002422931,0.00004524439,0.0000209079,0.00001696669,0.00003428328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002828779,0.00001237351,0.0003233292,0.00002064748,0.000003011998,0.00006737542,0.00001310228,0.00003747047,0.9978129,0.0001215392,0.0001161466,0.001189306],"study_design_scores_gemma":[0.00005226348,0.0001294326,0.01854174,0.000007564224,0.000007830051,0.0004854155,0.00005461069,0.001190387,0.976066,0.0002804417,0.00317913,0.000005287986],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881204,0.001857438,0.005147407,0.0005524319,0.0001095087,0.00003001286,0.001382964,0.0002358053,0.002564012],"genre_scores_gemma":[0.9914819,0.0003789569,0.002268612,0.00009875315,0.00001467373,0.00001891314,0.001909663,0.00004949508,0.003778967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003513439,"threshold_uncertainty_score":0.01175356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01636471796378529,"score_gpt":0.2790743907813173,"score_spread":0.262709672817532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}