{"id":"W4388020618","doi":"10.1002/cncr.35084","title":"Prognostic impact of lymph node involvement and loss of heterozygosity of 1p or 16q in stage III favorable histology Wilms tumor: A report from Children’s Oncology Group Studies AREN03B2 and AREN0532","year":2023,"lang":"en","type":"article","venue":"Cancer","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University; BC Children's Hospital","funders":"National Institutes of Health; National Cancer Institute; St. Baldrick's Foundation","keywords":"Medicine; Wilms' tumor; Internal medicine; Hazard ratio; Stage (stratigraphy); Loss of heterozygosity; Histology; Lymph node; Proportional hazards model; Prospective cohort study; Vincristine; Oncology; Gastroenterology; Chemotherapy; Confidence interval; Cyclophosphamide; Allele; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001012425,0.0002127056,0.000218225,0.0004683433,0.0001903478,0.0003124064,0.0002216006,0.0001756633,0.0006399119],"category_scores_gemma":[0.00125062,0.0001236542,0.0002610447,0.000515951,0.000248383,0.0001600462,0.0002544386,0.0001867167,0.00008002068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003166291,"about_ca_system_score_gemma":0.0002734248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003164303,"about_ca_topic_score_gemma":0.005647772,"domain_scores_codex":[0.9996743,0.0001004063,0.00003724365,0.00006385857,0.00009003707,0.00003399274],"domain_scores_gemma":[0.998726,0.0003629782,0.0005222598,0.00007211205,0.0001035822,0.0002130759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003976984,0.00001233417,0.9975044,0.00001350167,0.00005614826,0.0000698085,0.00005601941,0.00003182874,0.0004474387,0.000004936329,0.00005674086,0.001349213],"study_design_scores_gemma":[0.00002887579,0.0002009671,0.9988354,0.000004398204,0.00004766351,0.0003592583,0.00005554442,0.00003354122,0.000207502,0.000003823941,0.0002212682,0.000001975279],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999466,0.000253997,0.00001403723,0.00000991019,0.000001091621,0.00000293717,0.0001550178,4.072173e-7,0.00009664657],"genre_scores_gemma":[0.9993111,0.0001257851,0.00003174808,0.000008140638,0.000004330856,0.000005050253,0.0004630507,6.831359e-7,0.00005015816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003164303,"threshold_uncertainty_score":0.006291747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02245544262048843,"score_gpt":0.3215373911606859,"score_spread":0.2990819485401975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}