{"id":"W4388033236","doi":"10.1038/s41409-023-02131-z","title":"Post-transplantation cyclophosphamide is associated with increased bacterial infections","year":2023,"lang":"en","type":"article","venue":"Bone Marrow Transplantation","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Cancer Moonshot; Moonshot Research and Development Program; National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; Office of Naval Research; Legend Biotech; Takeda Oncology; Health Resources and Services Administration; National Institutes of Health; MorphoSys; Omeros Corporation; Astellas Pharma; Adaptive Biotechnologies; Pfizer; Incyte; Kiadis Pharma; bluebird bio; Jazz Pharmaceuticals; Actinium Pharmaceuticals; CareDx; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; CSL Behring; BeiGene; HistoGenetics; Atara Biotherapeutics; National Cancer Institute; Servier; Gilead Sciences; Conselho Nacional de Desenvolvimento Científico e Tecnológico; GlaxoSmithKline; Gateway for Cancer Research; Alexion Pharmaceuticals; Agios Pharmaceuticals; Mallinckrodt Pharmaceuticals; Fundação de Amparo à Pesquisa do Estado de São Paulo; Cidara Therapeutics; Astellas Pharma US; Amgen","keywords":"Medicine; Cohort; Internal medicine; Transplantation; Cyclophosphamide; Incidence (geometry); Immunology; Gastroenterology; Graft-versus-host disease; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003273486,0.0003942192,0.0004587054,0.0006530798,0.0003713178,0.0007697769,0.0002175726,0.0005356955,0.002753783],"category_scores_gemma":[0.002331987,0.0001656871,0.0004055465,0.0008453405,0.0002758839,0.0002506313,0.0002641882,0.001084568,0.0002636128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003515663,"about_ca_system_score_gemma":0.0004218704,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008799314,"about_ca_topic_score_gemma":0.0009671468,"domain_scores_codex":[0.9993375,0.0001741478,0.00006692312,0.00007569004,0.0001877077,0.0001579325],"domain_scores_gemma":[0.9959821,0.0007483347,0.002520056,0.0001572051,0.0001889049,0.0004034965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004570487,0.000527306,0.9576782,0.0001445779,0.0002792662,0.004650613,0.00008839952,0.00008544352,0.01580936,0.0001076593,0.0004646155,0.015594],"study_design_scores_gemma":[0.00002045772,0.0006196645,0.9902511,0.00003304466,0.0001228879,0.006868245,0.00007931516,0.0001160905,0.001326041,0.00004267188,0.0005137004,0.000006846676],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960788,0.001778099,0.0001826067,0.0001194326,0.00002355897,0.00001200408,0.0001279797,0.00002030017,0.001657291],"genre_scores_gemma":[0.9989053,0.000412426,0.0001398586,0.00007064416,0.00003741824,0.000006394635,0.0001439454,0.000005539967,0.0002784789],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002753783,"threshold_uncertainty_score":0.009212375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01046023720701022,"score_gpt":0.2390943516992094,"score_spread":0.2286341144921992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}