{"id":"W4388033236","doi":"10.1038/s41409-023-02131-z","title":"Post-transplantation cyclophosphamide is associated with increased bacterial infections","year":2023,"lang":"en","type":"article","venue":"Bone Marrow Transplantation","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Cancer Moonshot; Moonshot Research and Development Program; National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; Office of Naval Research; Legend Biotech; Takeda Oncology; Health Resources and Services Administration; National Institutes of Health; MorphoSys; Omeros Corporation; Astellas Pharma; Adaptive Biotechnologies; Pfizer; Incyte; Kiadis Pharma; bluebird bio; Jazz Pharmaceuticals; Actinium Pharmaceuticals; CareDx; National Heart, Lung, and Blood Institute; Novartis Pharmaceuticals Corporation; Bristol-Myers Squibb; CSL Behring; BeiGene; HistoGenetics; Atara Biotherapeutics; National Cancer Institute; Servier; Gilead Sciences; Conselho Nacional de Desenvolvimento Científico e Tecnológico; GlaxoSmithKline; Gateway for Cancer Research; Alexion Pharmaceuticals; Agios Pharmaceuticals; Mallinckrodt Pharmaceuticals; Fundação de Amparo à Pesquisa do Estado de São Paulo; Cidara Therapeutics; Astellas Pharma US; Amgen","keywords":"Medicine; Cohort; Internal medicine; Transplantation; Cyclophosphamide; Incidence (geometry); Immunology; Gastroenterology; Graft-versus-host disease; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004033184,0.0003614757,0.0004627739,0.0004978343,0.0002461386,0.0000599553,0.00007614507,0.0002626514,0.0004678656],"category_scores_gemma":[0.0000487134,0.0003400322,0.0001499557,0.001118122,0.00008893987,0.0003314302,0.000003899894,0.0002501311,0.0003555238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001196506,"about_ca_system_score_gemma":0.0002435746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004095699,"about_ca_topic_score_gemma":0.0005384409,"domain_scores_codex":[0.997543,0.0001394402,0.0006018076,0.0005217295,0.0006946236,0.0004993968],"domain_scores_gemma":[0.998674,0.0003479794,0.0001801092,0.0002759087,0.0002838231,0.0002382287],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.008728637,0.0008984994,0.1761275,0.003484141,0.0008368324,0.004732646,0.01308322,0.0002447355,0.7886744,0.0004967606,0.001088541,0.001604075],"study_design_scores_gemma":[0.01243277,0.001002789,0.8638359,0.001343762,0.001944616,0.002202206,0.0002917544,0.0005098265,0.1153515,0.0001103734,0.0002825232,0.0006919834],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906378,0.00001903455,0.002431752,0.0006981696,0.0002933051,0.001045652,0.0008873302,0.0008633842,0.003123574],"genre_scores_gemma":[0.9849721,0.0007359598,0.0004227281,0.0004497349,0.0001046158,0.0001601776,0.01243926,0.00008898701,0.0006264454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6877084,"threshold_uncertainty_score":0.9999052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01046023720701022,"score_gpt":0.2390943516992094,"score_spread":0.2286341144921992,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}