{"id":"W4388034582","doi":"10.1111/apt.17755","title":"Open‐label, clinical trial extension: Two‐year safety and efficacy results of seladelpar in patients with primary biliary cholangitis","year":2023,"lang":"en","type":"article","venue":"Alimentary Pharmacology & Therapeutics","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Toronto Liver Centre","funders":"National Institute for Health and Care Research; CymaBay Therapeutics","keywords":"Medicine; Tolerability; Cholestasis; Internal medicine; Gastroenterology; Bilirubin; Alkaline phosphatase; Clinical endpoint; Adverse effect; Liver injury; Primary biliary cirrhosis; Ursodeoxycholic acid; Steatohepatitis; Clinical trial; Fatty liver","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007419697,0.0001892742,0.0005468142,0.0001192003,0.0000855787,0.00001066569,0.0002324019,0.0001015643,0.0001029176],"category_scores_gemma":[0.000002229048,0.0001504486,0.00005492397,0.000355429,0.0002772178,0.0001582538,0.0003819499,0.0003810201,0.00001882929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000611752,"about_ca_system_score_gemma":0.0001604373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009716326,"about_ca_topic_score_gemma":0.000002848757,"domain_scores_codex":[0.9979103,0.0004546477,0.0007089903,0.0003993435,0.0002342274,0.0002924493],"domain_scores_gemma":[0.9987638,0.0004653845,0.0001889916,0.0003368993,0.00009345594,0.0001514547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5945976,0.008379726,0.3768086,0.00005861876,0.0054941,0.0001145414,0.0003859408,0.000009134408,0.001920352,0.000007105487,0.002408535,0.009815723],"study_design_scores_gemma":[0.2999491,0.005304981,0.6891576,0.0000555042,0.002997243,0.000003320132,0.00007874309,0.00005881548,0.0002889654,0.000008944916,0.001961043,0.0001356767],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950356,0.0003088886,3.986871e-7,0.001847781,0.0005306556,0.001805838,0.0001845985,0.00004046791,0.0002457977],"genre_scores_gemma":[0.9853482,0.002603149,0.0002620815,0.01065867,0.0001598982,0.0000180944,0.000807827,0.00003467975,0.0001074644],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.312349,"threshold_uncertainty_score":0.6135114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09639709592743903,"score_gpt":0.4060993288660343,"score_spread":0.3097022329385952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}