{"id":"W4388034582","doi":"10.1111/apt.17755","title":"Open‐label, clinical trial extension: Two‐year safety and efficacy results of seladelpar in patients with primary biliary cholangitis","year":2023,"lang":"en","type":"article","venue":"Alimentary Pharmacology & Therapeutics","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Toronto Liver Centre","funders":"National Institute for Health and Care Research; CymaBay Therapeutics","keywords":"Medicine; Tolerability; Cholestasis; Internal medicine; Gastroenterology; Bilirubin; Alkaline phosphatase; Clinical endpoint; Adverse effect; Liver injury; Primary biliary cirrhosis; Ursodeoxycholic acid; Steatohepatitis; Clinical trial; Fatty liver","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003727379,0.001116278,0.00179509,0.0003816614,0.0003537521,0.0009232505,0.0006218398,0.001182395,0.003948401],"category_scores_gemma":[0.00240722,0.0003651778,0.00164641,0.0003931056,0.001014231,0.001082289,0.0004399431,0.002664602,0.0007565925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005385356,"about_ca_system_score_gemma":0.0009307563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003920082,"about_ca_topic_score_gemma":0.0006921771,"domain_scores_codex":[0.9988335,0.0006891062,0.00008014102,0.0001394009,0.00009809256,0.0001597716],"domain_scores_gemma":[0.9971608,0.0006469752,0.0006659086,0.0004644213,0.0003124484,0.0007495234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8870415,0.03671664,0.006976246,0.0006723007,0.001122314,0.0002528045,0.0002876896,0.0007931245,0.01670614,0.0001096604,0.001298255,0.04802334],"study_design_scores_gemma":[0.419642,0.5515194,0.02251184,0.00004107347,0.000564198,0.000277658,0.00008123664,0.0006545189,0.003067723,0.00009627597,0.001513747,0.00003029877],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963033,0.001198027,0.0003429605,0.0001996802,0.00005418511,0.0006038911,0.0005515461,0.00004828649,0.0006981631],"genre_scores_gemma":[0.9943071,0.0006794213,0.0007885473,0.0003527276,0.0001885003,0.0009268697,0.001646073,0.00001608393,0.001094777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003948401,"threshold_uncertainty_score":0.01971251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09639709592743903,"score_gpt":0.4060993288660343,"score_spread":0.3097022329385952,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}