{"id":"W4388036682","doi":"10.1016/j.jtct.2023.10.018","title":"Donor-Derived Malignancy and Transplantation Morbidity: Risks of Patient and Donor Genetics in Allogeneic Hematopoietic Stem Cell Transplantation","year":2023,"lang":"en","type":"review","venue":"Transplantation and Cellular Therapy","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; Office of Naval Research; National Heart, Lung, and Blood Institute; Genentech; Health Resources and Services Administration; Swedish Orphan Biovitrum; National Institute of Environmental Health Sciences; Servier; Gateway for Cancer Research; Astellas Pharma; Sanofi; MacroGenics; Incyte; Leukemia and Lymphoma Society","keywords":"Hematopoietic stem cell transplantation; Medicine; Transplantation; Genetic testing; Germline; Oncology; CEBPA; Immunology; Internal medicine; Genetics; Biology; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003741112,0.0005594503,0.001419095,0.0005776287,0.00008943513,0.00004129804,0.0001114267,0.0004796736,0.00002466788],"category_scores_gemma":[0.000001372677,0.0004869404,0.0001775786,0.0004050432,0.0001744451,0.00009309014,0.00000944697,0.0004494723,0.000008906328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006781118,"about_ca_system_score_gemma":0.0002188527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002261321,"about_ca_topic_score_gemma":0.00007756805,"domain_scores_codex":[0.9970295,0.0003976801,0.001073959,0.0006945326,0.0004166529,0.0003877087],"domain_scores_gemma":[0.9988838,0.00024799,0.0003293491,0.0002621032,0.00006808395,0.0002086255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001386472,0.000265639,0.001237941,0.1595044,0.0004450964,0.001329401,0.01494691,0.00001585445,0.01215348,0.00007022962,0.000007763198,0.8086368],"study_design_scores_gemma":[0.1337966,0.0143213,0.04747292,0.1944061,0.0385301,0.01621547,0.01044317,0.001804186,0.4547561,0.001220361,0.07367151,0.0133622],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.4148305,0.5827012,0.0004553959,0.00002349176,0.00005212958,0.001618239,0.0002383938,0.00003727241,0.00004330382],"genre_scores_gemma":[0.05442598,0.9436996,0.0002378527,0.00003861861,0.00003288438,0.0001773307,0.001205478,0.0001076911,0.00007458247],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7952746,"threshold_uncertainty_score":0.9997582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09424667534191573,"score_gpt":0.3399268667014665,"score_spread":0.2456801913595508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}