{"id":"W4388037336","doi":"10.1016/j.bbi.2023.10.022","title":"Gasdermin D activation in oligodendrocytes and microglia drives inflammatory demyelination in progressive multiple sclerosis","year":2023,"lang":"en","type":"article","venue":"Brain Behavior and Immunity","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Medical Council of Canada; ArcelorMittal (Canada); University of Alberta; McMaster University Medical Centre; Canada Auto Workers; Vancouver Infectious Diseases Centre; Ottawa Fertility Centre; Muscular Dystrophy Canada; Cargill (Canada)","funders":"Canadian Institutes of Health Research; Multiple Sclerosis Society of Canada; Nihon Medi-Physics","keywords":"Microglia; Multiple sclerosis; Neuroinflammation; White matter; Oligodendrocyte; Inflammasome; Pathogenesis; Central nervous system; Pathology; Hippocampal formation; Inflammation; Biology; Chemistry; Myelin; Medicine; Immunology; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002332359,0.0002641973,0.0003300114,0.0005871296,0.0002520942,0.0003584428,0.0001631167,0.0004201454,0.001023621],"category_scores_gemma":[0.0002276089,0.0002159523,0.0002402646,0.0002781675,0.0005714502,0.0002372602,0.000369019,0.0005274598,0.0002237963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003668023,"about_ca_system_score_gemma":0.0001993486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006465535,"about_ca_topic_score_gemma":0.001293554,"domain_scores_codex":[0.9997545,0.00005154133,0.00003057202,0.00004776136,0.00005479168,0.00006079885],"domain_scores_gemma":[0.9998547,0.00001632383,0.00004695251,0.00001761074,0.00001916247,0.00004517588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006737813,0.00005032854,0.004345284,0.00004431236,0.00001389984,0.0004951235,0.0001319965,0.00007102358,0.9926063,0.0001254159,0.00005892527,0.001383672],"study_design_scores_gemma":[0.0001717197,0.001159703,0.2878652,0.00004233936,0.0001291443,0.005418286,0.001558385,0.001810657,0.6968623,0.00140666,0.003547834,0.0000277487],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986609,0.0004757043,0.0003480485,0.00005059928,0.000008249865,0.000005320426,0.00009766261,0.00001942806,0.0003340881],"genre_scores_gemma":[0.9987522,0.0002060993,0.0002981234,0.00003052835,0.000006918031,0.00001028739,0.00006673508,0.000005453279,0.000623686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001023621,"threshold_uncertainty_score":0.003424346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01685725907715229,"score_gpt":0.2540060823917442,"score_spread":0.2371488233145919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}