{"id":"W4388037336","doi":"10.1016/j.bbi.2023.10.022","title":"Gasdermin D activation in oligodendrocytes and microglia drives inflammatory demyelination in progressive multiple sclerosis","year":2023,"lang":"en","type":"article","venue":"Brain Behavior and Immunity","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Medical Council of Canada; ArcelorMittal (Canada); University of Alberta; McMaster University Medical Centre; Canada Auto Workers; Vancouver Infectious Diseases Centre; Ottawa Fertility Centre; Muscular Dystrophy Canada; Cargill (Canada)","funders":"Canadian Institutes of Health Research; Multiple Sclerosis Society of Canada; Nihon Medi-Physics","keywords":"Microglia; Multiple sclerosis; Neuroinflammation; White matter; Oligodendrocyte; Inflammasome; Pathogenesis; Central nervous system; Pathology; Hippocampal formation; Inflammation; Biology; Chemistry; Myelin; Medicine; Immunology; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002437089,0.0001255127,0.0001150115,0.0001692274,0.00009789907,0.00002875899,0.00007670869,0.000141515,0.000003426673],"category_scores_gemma":[0.0001699213,0.0001357974,0.00002537984,0.0001701301,0.0001002377,0.00002433803,0.0001252819,0.0001313363,0.000002079644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001392077,"about_ca_system_score_gemma":0.00002832743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001056459,"about_ca_topic_score_gemma":0.0002092239,"domain_scores_codex":[0.9992293,0.0001108326,0.0001998537,0.0002017029,0.00005927618,0.0001990452],"domain_scores_gemma":[0.9996981,0.0000366012,0.00005908476,0.0001453389,0.00003400924,0.00002688946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004325092,0.00004867572,0.2720283,0.00001578164,0.000003714443,0.000002064929,0.0005549127,0.000003158091,0.7125013,0.000005162528,0.00004104903,0.01475256],"study_design_scores_gemma":[0.0008880282,0.00005679705,0.7326888,0.00004314805,0.000003951911,0.000002315378,0.001003483,0.00004731537,0.2649556,0.00001661154,0.0001714041,0.0001225026],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989983,0.0004930731,0.000005415114,0.0001068344,0.00002819837,0.0003189715,0.000005408935,0.00001539704,0.000028361],"genre_scores_gemma":[0.9989904,0.0004549797,0.00005494938,0.0000533548,0.00001465432,0.0001314887,0.0002089435,0.00001432292,0.00007694501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4606605,"threshold_uncertainty_score":0.5537656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01685725907715229,"score_gpt":0.2540060823917442,"score_spread":0.2371488233145919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}