{"id":"W4388042143","doi":"10.1172/jci157165","title":"Single-cell transcriptomics and chromatin accessibility profiling elucidate the kidney-protective mechanism of mineralocorticoid receptor antagonists","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Nutrition, Metabolism and Diabetes","funders":"Perelman School of Medicine, University of Pennsylvania; National Institutes of Health; OeAD-GmbH; Medizinische Universität Graz; National Institute of Diabetes and Digestive and Kidney Diseases; Karl-Franzens-Universität Graz; Deutsche Forschungsgemeinschaft; University of Pennsylvania","keywords":"Mineralocorticoid receptor; Endocrinology; Epithelial sodium channel; Internal medicine; Mineralocorticoid; Kidney; Albuminuria; Aldosterone; Kidney disease; Distal convoluted tubule; Biology; Medicine; Chemistry; Reabsorption; Sodium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001874863,0.0001557585,0.000388154,0.0002623504,0.0001388055,0.0003732916,0.0001490627,0.0002118338,0.0006414662],"category_scores_gemma":[0.0001598487,0.0001262648,0.0002509922,0.0002177735,0.000164032,0.0002249005,0.0001691885,0.0002806957,0.0002293812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001482958,"about_ca_system_score_gemma":0.0001485912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004768303,"about_ca_topic_score_gemma":0.001366649,"domain_scores_codex":[0.9998442,0.00001464382,0.000008004426,0.00005914994,0.0000497611,0.00002434032],"domain_scores_gemma":[0.9998903,0.00002847272,0.00002538507,0.00001487511,0.00002417294,0.00001670579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003309542,0.000005707808,0.0008776036,0.00002329489,0.000006343089,0.00001157312,0.00001400468,0.00007614941,0.9971752,0.00004981101,0.00002164031,0.001705614],"study_design_scores_gemma":[0.00001325507,0.0002900396,0.1197248,0.000008824228,0.00006282402,0.0002378688,0.0001724208,0.006797199,0.8677863,0.0003842485,0.004503939,0.00001825339],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9603407,0.00435685,0.03087206,0.0001539439,0.00004426834,0.0000507982,0.002478152,0.0001531471,0.001550123],"genre_scores_gemma":[0.9823072,0.002263078,0.01142908,0.0001437464,0.0000337509,0.0000718282,0.001643403,0.00003608368,0.002071836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006414662,"threshold_uncertainty_score":0.002145886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1026916581752844,"score_gpt":0.3574689079372215,"score_spread":0.2547772497619371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}