{"id":"W4388042466","doi":"10.1136/jitc-2023-sitc2023.1118","title":"1118 The iodinated fluorescein derivative PV-10 enhances the antiviral activity of CD8+ T-Cells by inducing STING dimerization: implications for enhanced vaccine applications","year":2023,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Alberta Bible College","funders":"Alberta Children's Hospital Foundation; Children's Hospital Foundation","keywords":"Cytotoxic T cell; Sting; Adjuvant; CD8; Cytotoxicity; Chemistry; Medicine; Immunology; Immune system; Biology; Molecular biology; Cancer research; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004927461,0.0002082139,0.0002741772,0.00007853498,0.0007403963,0.00004563993,0.0002982095,0.0001634204,0.00001541162],"category_scores_gemma":[0.0004219811,0.0001393455,0.00008720363,0.0003974487,0.0004808426,0.0001451868,0.00008755652,0.0002353781,0.00003050241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000022898,"about_ca_system_score_gemma":0.0001339226,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006500585,"about_ca_topic_score_gemma":0.00001200275,"domain_scores_codex":[0.9987033,0.0002093712,0.0003824648,0.0003240709,0.00004917273,0.0003316187],"domain_scores_gemma":[0.9984697,0.0006175553,0.0003352471,0.0003774645,0.0001623095,0.00003769295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008262257,0.00004148618,0.000122058,0.00003566822,0.0001296147,9.622999e-8,0.0006064259,0.00001632526,0.9909426,0.0005325329,0.005329765,0.002160799],"study_design_scores_gemma":[0.0004287497,0.00009841978,0.01799379,0.00005397548,0.00005792843,0.000006456009,0.0004386041,0.00003120144,0.9707637,0.000314804,0.009657676,0.0001546937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929062,0.0006047423,0.001928349,0.002998284,0.0002076873,0.0009018219,0.0001697592,0.00009591035,0.0001872957],"genre_scores_gemma":[0.9974745,0.000139452,0.00006581221,0.0001001326,0.00003574683,0.0003086259,0.000204169,0.00002305154,0.001648516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02017891,"threshold_uncertainty_score":0.5694605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01627169076901417,"score_gpt":0.2621915126719617,"score_spread":0.2459198219029476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}