{"id":"W4388042528","doi":"10.1136/jitc-2023-sitc2023.0689","title":"689 Pharmacodynamic results with talquetamab and daratumumab in patients with relapsed/refractory multiple myeloma in TRIMM-2","year":2023,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"","keywords":"Daratumumab; Medicine; CD38; Pharmacodynamics; Internal medicine; Multiple myeloma; CD8; Oncology; Refractory (planetary science); Antibody; Monoclonal antibody; Pharmacology; Immunology; Gastroenterology; Bortezomib; Immune system; Pharmacokinetics; Stem cell; Biology; CD34","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004677588,0.0002971485,0.0009248331,0.0002483996,0.0001976313,0.0005548963,0.0001905801,0.0003947016,0.001898006],"category_scores_gemma":[0.0006584134,0.0001493508,0.0008220193,0.0002410385,0.0001903919,0.0003240371,0.0001830083,0.0009819252,0.0003948915],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005226394,"about_ca_system_score_gemma":0.0003391639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005999689,"about_ca_topic_score_gemma":0.001250018,"domain_scores_codex":[0.9998088,0.00006736035,0.00001389871,0.00003722891,0.00003227562,0.00004037558],"domain_scores_gemma":[0.9997305,0.00006300279,0.0000645959,0.00001426253,0.00001695547,0.0001107308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4267815,0.01324751,0.1134889,0.0007015785,0.003480867,0.001563194,0.0004593687,0.00687431,0.1593176,0.0003056841,0.005835525,0.267944],"study_design_scores_gemma":[0.08382152,0.3303176,0.5012854,0.0001012259,0.004237644,0.004164089,0.0003096949,0.01542806,0.04025934,0.0007048008,0.01922332,0.0001472452],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963462,0.001822643,0.0001424196,0.0001953051,0.00002568429,0.00007478586,0.0003223374,0.00003386717,0.00103672],"genre_scores_gemma":[0.9984223,0.0003003159,0.0001962339,0.0002282997,0.00004403293,0.0000386712,0.000429953,0.000008713138,0.0003315971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001898006,"threshold_uncertainty_score":0.006349504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01426746225719454,"score_gpt":0.255296573393422,"score_spread":0.2410291111362274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}