{"id":"W4388042528","doi":"10.1136/jitc-2023-sitc2023.0689","title":"689 Pharmacodynamic results with talquetamab and daratumumab in patients with relapsed/refractory multiple myeloma in TRIMM-2","year":2023,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"","keywords":"Daratumumab; Medicine; CD38; Pharmacodynamics; Internal medicine; Multiple myeloma; CD8; Oncology; Refractory (planetary science); Antibody; Monoclonal antibody; Pharmacology; Immunology; Gastroenterology; Bortezomib; Immune system; Pharmacokinetics; Stem cell; Biology; CD34","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006965243,0.0003509132,0.0005334322,0.0005808095,0.00009901918,0.00006509749,0.0001119903,0.0001950583,0.0000155455],"category_scores_gemma":[0.0003450854,0.0002753671,0.00004023201,0.0008645481,0.0004628356,0.0002946041,0.00006913094,0.0007346494,0.00001515691],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001990949,"about_ca_system_score_gemma":0.0003749583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004202611,"about_ca_topic_score_gemma":0.0006004384,"domain_scores_codex":[0.9973047,0.0001214456,0.0005211228,0.0007027955,0.0007097589,0.0006401205],"domain_scores_gemma":[0.9985483,0.0001573104,0.0001418722,0.000418294,0.0001069756,0.000627241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01052664,0.0004956867,0.9368231,0.0004029242,0.0001662675,0.001417916,0.001733656,0.0001885867,0.04001673,0.00001546938,0.001148754,0.007064295],"study_design_scores_gemma":[0.02462733,0.0009638788,0.9647894,0.0005794489,0.0000445674,0.00007081065,0.0002045868,0.0009034181,0.004388939,0.0000341611,0.003049015,0.0003444461],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968324,0.0002666258,7.53477e-7,0.000617281,0.00008523347,0.001035443,0.00004801195,0.0001077086,0.001006508],"genre_scores_gemma":[0.9974151,0.0002245841,0.0001835817,0.0001224042,0.00005476113,0.00004891987,0.0002337323,0.00008066261,0.001636254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03562779,"threshold_uncertainty_score":0.9999698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01426746225719454,"score_gpt":0.255296573393422,"score_spread":0.2410291111362274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}