{"id":"W4388042546","doi":"10.1136/jitc-2023-sitc2023.0601","title":"601 Identification of non-squamous NSCLC molecular subtypes and association with outcomes in the phase 3 IMpower150 study of 1L atezolizumab ± bevacizumab + carboplatin-paclitaxel in metastatic NSCLC","year":2023,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"F. Hoffmann-La Roche","keywords":"Carboplatin; Atezolizumab; Bevacizumab; Medicine; Internal medicine; Paclitaxel; Oncology; Population; Chemotherapy; Cancer research; Cancer; Immunotherapy; Cisplatin; Nivolumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001059828,0.0002985655,0.0005289234,0.0002105138,0.0002157249,0.0005471684,0.0003868413,0.0003656359,0.001642902],"category_scores_gemma":[0.0007595627,0.0003024617,0.0006719297,0.0002157539,0.0002592072,0.0002286052,0.000296181,0.0007284613,0.0002793233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000323879,"about_ca_system_score_gemma":0.0004590643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006775699,"about_ca_topic_score_gemma":0.001636785,"domain_scores_codex":[0.9996781,0.0001259121,0.00002483845,0.00006312904,0.00006540317,0.00004258642],"domain_scores_gemma":[0.9995992,0.00007532685,0.0001149358,0.00005433699,0.00003993428,0.0001162527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.336529,0.008161561,0.4975393,0.0004956985,0.002333528,0.0002828977,0.0003273319,0.001031935,0.07470684,0.0001945052,0.003554801,0.0748426],"study_design_scores_gemma":[0.0219841,0.05648838,0.9065037,0.0000346395,0.001420492,0.000484003,0.00009936454,0.002057991,0.007851298,0.0001525907,0.002894549,0.00002875391],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987593,0.000355039,0.00009257285,0.00003742754,0.000007007549,0.00009156077,0.0003593934,0.000007825407,0.0002899737],"genre_scores_gemma":[0.9972313,0.0001408223,0.0002706426,0.0001486909,0.00002142715,0.0001411516,0.001530488,0.000006606496,0.000508928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001642902,"threshold_uncertainty_score":0.005604982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0100293777047789,"score_gpt":0.2723889858369495,"score_spread":0.2623596081321706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}