{"id":"W4388042546","doi":"10.1136/jitc-2023-sitc2023.0601","title":"601 Identification of non-squamous NSCLC molecular subtypes and association with outcomes in the phase 3 IMpower150 study of 1L atezolizumab ± bevacizumab + carboplatin-paclitaxel in metastatic NSCLC","year":2023,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada)","funders":"F. Hoffmann-La Roche","keywords":"Carboplatin; Atezolizumab; Bevacizumab; Medicine; Internal medicine; Paclitaxel; Oncology; Population; Chemotherapy; Cancer research; Cancer; Immunotherapy; Cisplatin; Nivolumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000749696,0.0001720804,0.0003150965,0.0001365895,0.00004055709,0.00003700569,0.0001256835,0.00009270688,4.265518e-7],"category_scores_gemma":[0.0005909773,0.0001399678,0.00004165587,0.0002625219,0.00009152024,0.00001314971,0.00005068195,0.0001066504,5.179706e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003497257,"about_ca_system_score_gemma":0.000147598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007133413,"about_ca_topic_score_gemma":0.001014625,"domain_scores_codex":[0.9985707,0.0001026215,0.0005236838,0.0003119114,0.0002809559,0.0002100581],"domain_scores_gemma":[0.9990841,0.0001014082,0.0003394996,0.000309447,0.0000856616,0.0000798819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003055593,0.0008174787,0.3997148,0.0001905723,0.0002326205,0.00007994342,0.004396448,0.001489306,0.5917275,0.0001010078,0.0001451557,0.0007996671],"study_design_scores_gemma":[0.006488288,0.001154266,0.8415901,0.00005736043,0.0001746523,0.00001621774,0.00390331,0.0004419156,0.1454916,0.0003496579,0.00004907346,0.0002835607],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986771,0.000395965,0.00001737789,0.0001792736,0.00006094141,0.0005642587,0.00006347711,0.000005329488,0.00003630656],"genre_scores_gemma":[0.9996036,0.0001204087,0.00005869239,0.00004065671,0.00001402594,0.00004341281,0.00007654876,0.00001974739,0.00002288803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4462359,"threshold_uncertainty_score":0.5707723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0100293777047789,"score_gpt":0.2723889858369495,"score_spread":0.2623596081321706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}