{"id":"W4388042564","doi":"10.1136/jitc-2023-sitc2023.0695","title":"695 Efficacy and safety of trastuzumab deruxtecan (T-DXd) with durvalumab in patients with non-small cell lung cancer (HER2 altered NSCLC) who progressed on anti-PD1/PD-L1 therapy (HUDSON)","year":2023,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Durvalumab; Medicine; Internal medicine; Clinical endpoint; Oncology; Tremelimumab; Lung cancer; Trastuzumab; non-small cell lung cancer (NSCLC); Adverse effect; Cancer; Immunotherapy; Clinical trial; Nivolumab; Ipilimumab; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003597268,0.0004469242,0.0007201844,0.0002513023,0.0001346565,0.00005556164,0.0001280501,0.000185527,0.00001485886],"category_scores_gemma":[0.00002688245,0.0003208558,0.00007515775,0.0005971455,0.0004695054,0.0001347116,0.00002635175,0.0003117032,0.000001388959],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001333738,"about_ca_system_score_gemma":0.0005686631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007210397,"about_ca_topic_score_gemma":0.0002225629,"domain_scores_codex":[0.9976698,0.00007751281,0.0005456621,0.0006302589,0.0005376075,0.0005392319],"domain_scores_gemma":[0.9986871,0.00006792337,0.0003086149,0.0004150447,0.0001297238,0.0003915743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0180476,0.0008760779,0.9397039,0.0009931795,0.0006718037,0.00009704966,0.003019642,0.0001742692,0.0153484,0.00000893973,0.0006097518,0.02044935],"study_design_scores_gemma":[0.02229468,0.002102692,0.9470739,0.002245748,0.0001290787,0.00001376865,0.0001628904,0.0001192723,0.0248562,0.0000065252,0.0006016375,0.000393587],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959452,0.001245289,0.000004489465,0.0005324401,0.0001242323,0.001790232,0.00005276755,0.00007650938,0.0002288298],"genre_scores_gemma":[0.9978011,0.001160345,0.0002588654,0.0002766561,0.00007528964,0.00007573388,0.00007664251,0.00008804608,0.0001873288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02005576,"threshold_uncertainty_score":0.9999244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01045595203227388,"score_gpt":0.2406354814381965,"score_spread":0.2301795294059226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}