{"id":"W4388044341","doi":"10.1101/2023.10.30.564842","title":"Investigating the importance of surface exposed loops in the gonococcal HpuB transporter for hemoglobin binding and utilization","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Blood groups and transfusion","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Neisseria gonorrhoeae; Biology; Mutant; Hemoglobin; Phenotype; Bacterial outer membrane; Transporter; Computational biology; Microbiology; Gene; Genetics; Biochemistry; Escherichia coli","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001317301,0.0001728443,0.0001553574,0.00008185006,0.0001106625,0.0002092239,0.0002382208,0.0003205583,0.0008742348],"category_scores_gemma":[0.0001276678,0.00005729802,0.0001807799,0.00007350402,0.0001501111,0.0001485611,0.0001662623,0.0002965514,0.0002574152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002463949,"about_ca_system_score_gemma":0.0001650359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001189627,"about_ca_topic_score_gemma":0.0007127401,"domain_scores_codex":[0.9999391,0.00001571376,0.000005147094,0.000008593471,0.00001815825,0.00001333703],"domain_scores_gemma":[0.9999315,0.00001990668,0.00001977329,0.000005428426,0.00001008351,0.00001330304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002843622,0.0001046295,0.002158896,0.00007119021,0.00001360877,0.0002092978,0.00005272643,0.0003177419,0.9936399,0.0004429533,0.00008252407,0.002622141],"study_design_scores_gemma":[0.00005034397,0.0004806231,0.02057195,0.0000311392,0.00005838249,0.0005875351,0.0002766949,0.01592412,0.9570681,0.0003141057,0.004620834,0.00001626572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977836,0.0002969281,0.001243937,0.00008570577,0.00001017926,0.000008867282,0.0001034071,0.00001552179,0.0004519296],"genre_scores_gemma":[0.9981553,0.0001379192,0.0009492507,0.00003304411,0.00000321393,0.000006367509,0.0001732245,0.000006684264,0.0005351344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001189627,"threshold_uncertainty_score":0.002924562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05341040760087753,"score_gpt":0.2642457843573883,"score_spread":0.2108353767565107,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}