{"id":"W4388045586","doi":"10.26434/chemrxiv-2023-jj6ln","title":"Photosensitization Enables Pauson-Khand-type Reactions with Nitrenes","year":2023,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Synthesis and Catalytic Reactions","field":"Chemistry","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Genentech; Deutschen Konsortium für Translationale Krebsforschung; Paul Scherrer Institut; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ontario Genomics; Genome Canada; McGill University; Bayer; Pfizer; Deutsche Forschungsgemeinschaft; Deutsches Krebsforschungszentrum; Bristol-Myers Squibb","keywords":"Pericyclic reaction; Nitrene; Morpholine; Chemistry; Bicyclic molecule; Combinatorial chemistry; Stereochemistry; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002378649,0.000270374,0.0002004713,0.0001213847,0.0001592482,0.0002675887,0.0002778272,0.0003052587,0.001654786],"category_scores_gemma":[0.0002460224,0.000143921,0.0001914569,0.0001090316,0.0003016637,0.0004706061,0.0005684507,0.0006687941,0.0004619651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004342714,"about_ca_system_score_gemma":0.0001875796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003109744,"about_ca_topic_score_gemma":0.0004540157,"domain_scores_codex":[0.9998649,0.00001768239,0.000008194642,0.00005023758,0.00002775838,0.00003112416],"domain_scores_gemma":[0.9999352,0.00002301118,0.00001367557,0.00001340518,0.000006043188,0.000008615569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001190727,0.00004239508,0.0001532444,0.0002395867,0.00001251944,0.0002833745,0.0001880051,0.0009627434,0.9679911,0.01620189,0.0005370124,0.01326913],"study_design_scores_gemma":[0.0000146921,0.0002196624,0.0002529859,0.00001225774,0.000006126794,0.0002498335,0.00001747848,0.001848083,0.9847408,0.001061833,0.01156353,0.00001277889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8954574,0.004217519,0.06561118,0.0003701154,0.0001955597,0.0001339235,0.000316903,0.0004310312,0.03326632],"genre_scores_gemma":[0.9837455,0.00163448,0.009305106,0.00009033985,0.00001529145,0.0000545849,0.0001265515,0.00005407295,0.004974147],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001654786,"threshold_uncertainty_score":0.005535781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04053985069480178,"score_gpt":0.2558172344269807,"score_spread":0.2152773837321789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}