{"id":"W4388045586","doi":"10.26434/chemrxiv-2023-jj6ln","title":"Photosensitization Enables Pauson-Khand-type Reactions with Nitrenes","year":2023,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Synthesis and Catalytic Reactions","field":"Chemistry","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Genentech; Deutschen Konsortium für Translationale Krebsforschung; Paul Scherrer Institut; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Ontario Genomics; Genome Canada; McGill University; Bayer; Pfizer; Deutsche Forschungsgemeinschaft; Deutsches Krebsforschungszentrum; Bristol-Myers Squibb","keywords":"Pericyclic reaction; Nitrene; Morpholine; Chemistry; Bicyclic molecule; Combinatorial chemistry; Stereochemistry; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001187644,0.0003617213,0.0003842117,0.0001207528,0.0001901708,0.0001453062,0.0002337997,0.0004218278,0.0007029642],"category_scores_gemma":[0.000184378,0.0003188505,0.000146814,0.00026369,0.00008841715,0.00007171711,0.0001757474,0.0004904305,0.0003751116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000134664,"about_ca_system_score_gemma":0.0002209688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003715562,"about_ca_topic_score_gemma":0.00009521297,"domain_scores_codex":[0.9983931,0.00001209107,0.0003420979,0.0006529048,0.0002990424,0.0003007435],"domain_scores_gemma":[0.9982257,0.0001950305,0.000283533,0.0009491988,0.0002277612,0.0001187874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001208606,0.0003743332,0.00354623,0.001827241,0.001117701,0.0001079369,0.0004880632,0.001513911,0.9721643,0.0001970427,0.01547647,0.003065932],"study_design_scores_gemma":[0.0002466595,0.000009870048,0.0006545217,0.0008591001,0.000361758,0.00003738025,0.0007819661,0.0003371509,0.9528604,0.001043543,0.04216807,0.0006395998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9191965,0.0003115515,0.0002035292,0.0006435085,0.0008735434,0.00022161,0.00004787584,0.001230782,0.07727114],"genre_scores_gemma":[0.96075,0.0006393917,0.0002439104,0.00002683548,0.0007404417,0.0001514454,0.001198912,0.0001419954,0.0361071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04155351,"threshold_uncertainty_score":0.9999263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04053985069480178,"score_gpt":0.2558172344269807,"score_spread":0.2152773837321789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}