{"id":"W4388047619","doi":"10.1136/jitc-2023-sitc2023.0778","title":"778 TILVANCE-301, a phase 3 study of lifileucel tumor-infiltrating lymphocyte (TIL) cell therapy combined with pembrolizumab (pembro) vs pembro alone in treatment-naïve unresectable or metastatic melanoma","year":2023,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Pembrolizumab; Medicine; Melanoma; Cancer; Internal medicine; Oncology; Surgery; Immunotherapy; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001734693,0.001533043,0.001816995,0.0004435331,0.0005872796,0.001072324,0.001067581,0.00200255,0.005738661],"category_scores_gemma":[0.0008730602,0.000657143,0.001608192,0.0002770514,0.001058696,0.0009372074,0.0003296702,0.004107145,0.001332111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001102903,"about_ca_system_score_gemma":0.002511478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001531378,"about_ca_topic_score_gemma":0.005009654,"domain_scores_codex":[0.9995036,0.0002526163,0.00002196924,0.00006989593,0.00005552431,0.00009641601],"domain_scores_gemma":[0.999036,0.0001663364,0.000169569,0.00005950707,0.00005371962,0.0005148712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8323248,0.08862117,0.001774971,0.0005321907,0.0006606335,0.0001457992,0.000121339,0.001207853,0.03778022,0.0002700039,0.004697056,0.03186406],"study_design_scores_gemma":[0.605453,0.3863767,0.003297207,0.00002243924,0.0002446652,0.00008001075,0.00002873207,0.0007133961,0.002271001,0.0001581345,0.001328452,0.00002623313],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848316,0.001390061,0.0005072867,0.000800342,0.0004123605,0.00640967,0.001889386,0.0001545793,0.003604962],"genre_scores_gemma":[0.975836,0.001546504,0.002499647,0.002192277,0.0004957932,0.007292068,0.003317981,0.00007336109,0.006746521],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005738661,"threshold_uncertainty_score":0.01919776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04680987990646559,"score_gpt":0.3167563591817601,"score_spread":0.2699464792752946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}