{"id":"W4388048048","doi":"10.1136/jitc-2023-sitc2023.0582","title":"582 Analysis of the HR+/HER2- breast cancer tumor microenvironment following immune priming with pelareorep and atezolizumab using imaging mass cytometry – Results from the AWARE-1 trial","year":2023,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Oncolytics Biotech (Canada)","funders":"","keywords":"Atezolizumab; Medicine; Tumor microenvironment; Breast cancer; Immune system; Oncology; Internal medicine; Antibody; Triple-negative breast cancer; Cancer; Cancer research; Immunotherapy; Immunology; Nivolumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003586474,0.0002251243,0.0003026889,0.00008894414,0.0002913029,0.00009053859,0.0001972935,0.00006288478,0.000002966847],"category_scores_gemma":[0.0000917712,0.0001405637,0.000189543,0.0004543876,0.0003439999,0.00001709086,0.0001918184,0.0001374716,5.187068e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007127908,"about_ca_system_score_gemma":0.0002253349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00569219,"about_ca_topic_score_gemma":0.0004533407,"domain_scores_codex":[0.9983355,0.0001046207,0.0003417491,0.0004960902,0.000368638,0.0003533636],"domain_scores_gemma":[0.9990007,0.00004070676,0.0002300315,0.0005067268,0.00003514029,0.0001866487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003832481,0.00006469692,0.2510486,0.00004050268,0.003604718,0.0000996309,0.0005095042,0.001476665,0.7377766,0.000002642101,0.0001823668,0.001361553],"study_design_scores_gemma":[0.01076793,0.0001153539,0.8330517,0.0002323211,0.001615397,0.00004801295,0.0006364499,0.001415159,0.1514258,0.00003251537,0.000336132,0.0003232258],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966893,0.001580291,0.00003040834,0.0006301402,0.0001185302,0.0003642925,0.000561504,0.00001149661,0.00001399621],"genre_scores_gemma":[0.9991391,0.0002860194,0.0001191089,0.00007258348,0.0001096385,0.00002105954,0.0001701121,0.00002901904,0.00005332417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5863509,"threshold_uncertainty_score":0.8604927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01259663640010753,"score_gpt":0.2596904684011493,"score_spread":0.2470938320010418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}