{"id":"W4388048122","doi":"10.1136/jitc-2023-sitc2023.0738","title":"738 A phase 1/2 study investigating the safety and efficacy of autologous TAC T cells in subjects with unresectable, locally advanced or metastatic claudin 18.2+ solid tumors","year":2023,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Immunotherapy; Leukapheresis; Chimeric antigen receptor; Cancer research; Radioimmunotherapy; Stem cell; Immunology; Immune system; Antibody; Biology; CD34","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001264576,0.001071699,0.00128975,0.0003189049,0.0004798186,0.0006466552,0.0006037928,0.001066363,0.004925877],"category_scores_gemma":[0.0004736913,0.0004351817,0.0009904238,0.0002584585,0.0007681729,0.000492639,0.0001824456,0.002252894,0.001063779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006799449,"about_ca_system_score_gemma":0.001813057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001332941,"about_ca_topic_score_gemma":0.002329307,"domain_scores_codex":[0.9996537,0.0001425992,0.00001470635,0.00006301238,0.00003668216,0.00008934792],"domain_scores_gemma":[0.9995009,0.00007492206,0.00007234867,0.00004433397,0.00005415308,0.0002534965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5465207,0.2030859,0.007923618,0.0008074374,0.000826515,0.0007244151,0.0003730515,0.002107296,0.1544756,0.0004442706,0.008071602,0.07463969],"study_design_scores_gemma":[0.1210278,0.8638402,0.004941673,0.00001462077,0.0002433411,0.0002024894,0.00005152919,0.0006628783,0.006134918,0.000139171,0.002724983,0.00001650955],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890431,0.0007640322,0.0009835535,0.0003111175,0.0001385925,0.005190769,0.001391572,0.00009868419,0.002078648],"genre_scores_gemma":[0.9820474,0.0009226039,0.002446706,0.001080477,0.000230193,0.005413456,0.00215311,0.00004285949,0.005663169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004925877,"threshold_uncertainty_score":0.01647872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03770694743003553,"score_gpt":0.3355257030615537,"score_spread":0.2978187556315182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}