{"id":"W4388048242","doi":"10.1136/jitc-2023-sitc2023.0589","title":"589 RUBY trial post hoc analysis of number needed to treat and incremental costs per outcome of dostarlimab + carboplatin-paclitaxel (CP) vs placebo + CP for primary advanced/recurrent endometrial cancer","year":2023,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"GlaxoSmithKline (Canada)","funders":"","keywords":"Placebo; Medicine; Internal medicine; Number needed to treat; Population; Post-hoc analysis; Carboplatin; Clinical endpoint; Endometrial cancer; Oncology; Randomized controlled trial; Cancer; Confidence interval; Chemotherapy; Relative risk; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02083084,0.001878015,0.004535221,0.0006893323,0.0002524266,0.001606499,0.001957382,0.001799854,0.01759065],"category_scores_gemma":[0.02298195,0.0006918217,0.01096077,0.0005949663,0.001023643,0.002183793,0.001131529,0.004790315,0.001030222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001436605,"about_ca_system_score_gemma":0.002161023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001574254,"about_ca_topic_score_gemma":0.001332307,"domain_scores_codex":[0.9838144,0.01360238,0.0004272253,0.000807657,0.0005459672,0.0008024386],"domain_scores_gemma":[0.9802979,0.01604253,0.001593292,0.0008943461,0.0004924395,0.0006795344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.9599915,0.001586786,0.002648597,0.0009401427,0.01376294,0.0001080802,0.00004834197,0.006966523,0.0008131618,0.0007465522,0.002476842,0.009910386],"study_design_scores_gemma":[0.5159254,0.2701253,0.0401068,0.0005814797,0.04802033,0.0003352703,0.0002986711,0.1025461,0.005842477,0.00532272,0.01067008,0.0002252812],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9631469,0.004867097,0.006838754,0.001429104,0.001429387,0.007085803,0.006924893,0.0002986034,0.007979439],"genre_scores_gemma":[0.9760345,0.0006663016,0.005506675,0.0008053877,0.0003442735,0.006567881,0.002744902,0.0001523446,0.007177703],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02083084,"threshold_uncertainty_score":0.1101653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01701422471149164,"score_gpt":0.2957273220226049,"score_spread":0.2787130973111133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}