{"id":"W4388048531","doi":"10.1136/jitc-2023-sitc2023.1372","title":"1372 TriTCE Co-Stim: a novel trispecific T cell engager platform, with integrated CD28 costimulation, engineered to widen the therapeutic window for treatment of poorly infiltrated tumors","year":2023,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"CD28; Cancer research; T cell; CD3; Cytokine; In vivo; Antibody; Immunotherapy; Immunology; Chemistry; Immune system; Medicine; Biology; CD8","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000701026,0.0004062966,0.0006760263,0.000379207,0.0002066008,0.00009508789,0.000166389,0.0001727543,0.00005866142],"category_scores_gemma":[0.0003082084,0.0002583514,0.0001539595,0.001072533,0.0002963914,0.0001294441,0.00001608906,0.0002436056,0.00002023307],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002056598,"about_ca_system_score_gemma":0.0007433502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002173379,"about_ca_topic_score_gemma":0.00003103505,"domain_scores_codex":[0.9977126,0.00006698598,0.0005958718,0.000473119,0.0005899405,0.000561485],"domain_scores_gemma":[0.9976664,0.0006457131,0.0001701086,0.0005344637,0.0003762322,0.0006071209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002867461,0.0003826863,0.006558316,0.0002383502,0.0005450743,0.00006579397,0.003373964,0.003922984,0.9766834,0.0001143701,0.001957404,0.003290237],"study_design_scores_gemma":[0.01554464,0.004881358,0.1708417,0.0004396248,0.0004645722,0.0002241368,0.001979651,0.006605515,0.7621102,0.0001634112,0.03611256,0.0006325441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940056,0.0002956317,0.0004063831,0.00144237,0.00009382734,0.003093553,0.0001637049,0.0001696664,0.0003292836],"genre_scores_gemma":[0.9940372,0.00008369089,0.0006982161,0.0002035619,0.0001326797,0.0002266011,0.0003824269,0.0001011427,0.0041345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2145731,"threshold_uncertainty_score":0.9999869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05746762826388186,"score_gpt":0.3030686027193463,"score_spread":0.2456009744554645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}