{"id":"W4388048531","doi":"10.1136/jitc-2023-sitc2023.1372","title":"1372 TriTCE Co-Stim: a novel trispecific T cell engager platform, with integrated CD28 costimulation, engineered to widen the therapeutic window for treatment of poorly infiltrated tumors","year":2023,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"CD28; Cancer research; T cell; CD3; Cytokine; In vivo; Antibody; Immunotherapy; Immunology; Chemistry; Immune system; Medicine; Biology; CD8","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000911914,0.0002640185,0.00009906058,0.0001257905,0.0001004211,0.0002074798,0.00017635,0.0002759345,0.003060989],"category_scores_gemma":[0.00005966345,0.0000961355,0.0001177475,0.0001056318,0.0001283576,0.0001881152,0.0001796261,0.0003627379,0.0009632706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002314285,"about_ca_system_score_gemma":0.000218322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003246153,"about_ca_topic_score_gemma":0.0006226947,"domain_scores_codex":[0.9999055,0.000009367392,0.00000655838,0.00001890694,0.00003756467,0.00002219114],"domain_scores_gemma":[0.9999666,0.000004624111,0.0000112017,0.000003160975,0.00000654893,0.000007885391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004544304,0.0000157207,0.0001194672,0.00002542389,0.000002462438,0.00002967646,0.000008169633,0.0001597697,0.9970284,0.000214594,0.0001779413,0.002172976],"study_design_scores_gemma":[0.000005916839,0.0001131891,0.0003065201,0.000001132091,0.000003403891,0.0001262937,0.000006068984,0.0007382787,0.9960046,0.0000181618,0.002673743,0.000002585684],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9665179,0.001099881,0.02226382,0.0002191658,0.00006366622,0.00009344692,0.000913644,0.0003959264,0.00843251],"genre_scores_gemma":[0.9782481,0.0005461267,0.01199345,0.0001707747,0.00001263764,0.00008668233,0.0009511195,0.00006533349,0.007925996],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003060989,"threshold_uncertainty_score":0.01024008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05746762826388186,"score_gpt":0.3030686027193463,"score_spread":0.2456009744554645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}