{"id":"W4388048581","doi":"10.1172/jci166740","title":"Breast cancer immunopeptidomes contain numerous shared tumor antigens","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"Canadian Cancer Society","keywords":"Breast cancer; Immunogenicity; Triple-negative breast cancer; Cancer immunotherapy; Antigen; Immunotherapy; Cancer research; Cancer; Immune checkpoint; Blockade; Biology; Oncology; Medicine; Immunology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009600606,0.000339737,0.0002464407,0.0004730291,0.0002206545,0.0003046267,0.0001323946,0.0001951602,0.002648342],"category_scores_gemma":[0.0001699155,0.0001067435,0.0002001325,0.000503237,0.0001035113,0.0001626216,0.0002792786,0.0002506647,0.0007520911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002163519,"about_ca_system_score_gemma":0.000116932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003217766,"about_ca_topic_score_gemma":0.0004808206,"domain_scores_codex":[0.9998438,0.0000197711,0.00001292291,0.00004703262,0.00004826488,0.00002824654],"domain_scores_gemma":[0.9999042,0.00001641299,0.00003834557,0.0000115672,0.00001228866,0.00001718219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001540256,0.0000178193,0.006234831,0.00008547949,0.00003060841,0.0001965174,0.00002256479,0.0000531983,0.9834699,0.00009566202,0.0001283206,0.009511008],"study_design_scores_gemma":[0.0000377441,0.0006036087,0.3439416,0.00003915049,0.0001470453,0.009172992,0.0001757692,0.001189081,0.6103671,0.0004273385,0.03388142,0.00001716599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879532,0.004976754,0.002675382,0.00007982525,0.00002480585,0.0000266343,0.001619331,0.00005180965,0.00259216],"genre_scores_gemma":[0.9868383,0.002245666,0.004282805,0.0001204936,0.00002286545,0.00004415093,0.00332069,0.00002941484,0.003095759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002648342,"threshold_uncertainty_score":0.008859634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05626000602586655,"score_gpt":0.3624468597973799,"score_spread":0.3061868537715134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}