{"id":"W4388049619","doi":"10.1016/j.parkreldis.2023.105923","title":"Increased brain cholinergic innervation in isolated REM sleep behaviour disorder from prodromal multiple system atrophy","year":2023,"lang":"en","type":"letter","venue":"Parkinsonism & Related Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Concordia University; Hôpital du Sacré-Cœur de Montréal; Université du Québec à Montréal; Canadian Sleep & Circadian Network","funders":"National Institute on Aging; W. Garfield Weston Foundation; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canada Excellence Research Chairs, Government of Canada","keywords":"Atrophy; Parkinsonism; Neuroscience; Dementia with Lewy bodies; Progressive supranuclear palsy; Lewy body; Cholinergic; Neurology; Medicine; Parasomnia; Cholinergic neuron; Brainstem; REM sleep behavior disorder; Pathology; Dementia; Psychology; Polysomnography; Electroencephalography; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005089714,0.0005388688,0.001120373,0.001002829,0.001270499,0.000930528,0.001131146,0.01596748,0.002540241],"category_scores_gemma":[0.004203914,0.0004261786,0.0007243117,0.0005819885,0.00127461,0.001180294,0.0005397852,0.006878984,0.0009547668],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002090501,"about_ca_system_score_gemma":0.0007608032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004808855,"about_ca_topic_score_gemma":0.009171893,"domain_scores_codex":[0.9997101,0.00004858755,0.00005450855,0.00004189751,0.00007228478,0.00007256036],"domain_scores_gemma":[0.9982304,0.000958567,0.000196371,0.00007794186,0.0002442712,0.0002924453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"observational","study_design_scores_codex":[0.0006558081,0.00007834416,0.01424723,0.000189381,0.00006197788,0.9227213,0.0002240807,0.0001023303,0.002298005,0.0007807476,0.04362433,0.01501645],"study_design_scores_gemma":[0.0004724434,0.0004831374,0.05863782,0.0002785154,0.0001622887,0.9097716,0.0004543228,0.00152028,0.001632028,0.003804112,0.02271879,0.00006467057],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.4220757,0.02415227,0.00143733,0.4817568,0.01486022,0.0001467668,0.000431048,0.0003084418,0.05483136],"genre_scores_gemma":[0.8356944,0.004936574,0.0009903689,0.1087639,0.038566,0.00006060164,0.0001061713,0.00005913833,0.01082283],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01596748,"threshold_uncertainty_score":0.01516771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009047654766449597,"score_gpt":0.2268882446217326,"score_spread":0.217840589855283,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}