{"id":"W4388049884","doi":"10.1016/j.tibtech.2023.10.001","title":"Cancer-on-chip models for metastasis: importance of the tumor microenvironment","year":2023,"lang":"en","type":"review","venue":"Trends in biotechnology","topic":"3D Printing in Biomedical Research","field":"Engineering","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Cancer Center Amsterdam; Electronic Components and Systems for European Leadership; Horizon 2020 Framework Programme; Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Tumor microenvironment; Metastasis; Extracellular matrix; Cancer; Cancer metastasis; Cancer research; Cancer therapy; Cancer cell; Immune system; Biology; Medicine; Computational biology; Nanotechnology; Tumor cells; Immunology; Materials science; Internal medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004171111,0.0003593079,0.001209619,0.000884536,0.000030103,0.000005999444,0.001284704,0.0006530264,0.00005847138],"category_scores_gemma":[0.0001201481,0.00025005,0.0003702521,0.001429025,0.0003389748,0.00001484808,0.0003333199,0.001044484,0.00001856522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003671494,"about_ca_system_score_gemma":0.00005070706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001714493,"about_ca_topic_score_gemma":0.0001062654,"domain_scores_codex":[0.9979145,0.00005318782,0.0007470863,0.0004446284,0.0002609818,0.0005795943],"domain_scores_gemma":[0.9985442,0.0002734966,0.0001778211,0.0009531841,0.000007780081,0.000043557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000002348362,0.00002476999,0.000002331522,0.005837836,0.0001804768,0.000006026412,0.000008426883,0.0007595153,0.00001751574,0.001290769,0.0008830251,0.9909869],"study_design_scores_gemma":[0.0002540106,0.0000635633,0.0000113844,0.005985812,0.0001872359,0.000009029474,0.000009387167,0.004256089,0.0008004939,0.001453733,0.986599,0.0003703223],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007841032,0.9975525,0.0002131667,0.0003873808,0.0003855549,0.0005837349,0.000337506,0.0002599686,0.0002018381],"genre_scores_gemma":[0.0001931654,0.9976491,0.0007500044,0.00001312401,0.00004095742,0.0009789983,0.00002325462,0.000118313,0.0002331279],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9906166,"threshold_uncertainty_score":0.9999952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1049669712229964,"score_gpt":0.3686207492231571,"score_spread":0.2636537780001607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}