{"id":"W4388049965","doi":"10.1016/j.ctrv.2023.102649","title":"Molecular profiling in cholangiocarcinoma: A practical guide to next-generation sequencing","year":2023,"lang":"en","type":"review","venue":"Cancer Treatment Reviews","topic":"Cholangiocarcinoma and Gallbladder Cancer Studies","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Agence Nationale de la Recherche; Sociedad Española de Oncología Médica; European Commission; Incyte","keywords":"Medicine; DNA sequencing; Computational biology; Targeted therapy; Bioinformatics; Liquid biopsy; Molecular diagnostics; Profiling (computer programming); Disease; Gene; Internal medicine; Cancer; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004817442,0.001799273,0.001843252,0.004762146,0.000604444,0.002450642,0.002514387,0.004576496,0.007713788],"category_scores_gemma":[0.01066627,0.001474352,0.001299432,0.002403916,0.001479857,0.002902287,0.001654875,0.008564058,0.01125926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001064446,"about_ca_system_score_gemma":0.002142004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002450054,"about_ca_topic_score_gemma":0.005417766,"domain_scores_codex":[0.9970336,0.001070601,0.0004528362,0.0003140791,0.001018442,0.0001104456],"domain_scores_gemma":[0.9939234,0.003229504,0.0003673231,0.000334484,0.001773181,0.0003721714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001145011,0.0001156482,0.001037046,0.002906564,0.0001306117,0.001375617,0.0003334976,0.001270522,0.00856266,0.007933554,0.4653315,0.5108882],"study_design_scores_gemma":[0.0000299222,0.000086339,0.001047966,0.001513473,0.00005933269,0.00480551,0.00009695791,0.001149817,0.001609433,0.01075431,0.9787703,0.00007662866],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001271332,0.6779453,0.195958,0.07794004,0.01253655,0.0006786635,0.002405369,0.005216686,0.02604814],"genre_scores_gemma":[0.005807934,0.596338,0.3244075,0.03694107,0.009345737,0.001688239,0.003110069,0.0010474,0.02131416],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007713788,"threshold_uncertainty_score":0.02580523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.400813823778394,"score_gpt":0.4724980599402206,"score_spread":0.07168423616182656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}