{"id":"W4388069786","doi":"10.1002/ange.202315185","title":"A Colorimetric Biosensing Platform with Aptamers, Rolling Circle Amplification and Urease‐Mediated Litmus Test","year":2023,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Aptamer; Rolling circle replication; Litmus; Biosensor; Streptavidin; Chemistry; Urease; Combinatorial chemistry; Biotinylation; Nanotechnology; Multiplex; DNA; Biophysics; Biotin; Molecular biology; Urea; Biochemistry; Materials science; Biology; DNA polymerase; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000602002,0.0008404824,0.0004340645,0.0006009982,0.0002256606,0.0005542527,0.001018368,0.001296098,0.0006542597],"category_scores_gemma":[0.0006255768,0.0005449693,0.0004122808,0.000311701,0.0004195001,0.0007018841,0.0008333109,0.0007421732,0.0007039279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003518835,"about_ca_system_score_gemma":0.0002421827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002116197,"about_ca_topic_score_gemma":0.0002740418,"domain_scores_codex":[0.9990402,0.0001584796,0.00006051924,0.0002152067,0.0004497153,0.00007590494],"domain_scores_gemma":[0.9996307,0.0001003547,0.00009725076,0.00003925391,0.00007854612,0.0000538961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003609271,0.00002291162,0.00007412879,0.00004445745,0.000006708999,0.00005083261,0.00002258669,0.0001599262,0.9940867,0.0002214627,0.0001024286,0.005171724],"study_design_scores_gemma":[0.000005157204,0.0001272003,0.0001709562,0.000002393705,0.000006552646,0.0001560657,0.000006311807,0.003014433,0.9952133,0.00004342704,0.00124153,0.00001274699],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5797352,0.006298194,0.4020139,0.0006827031,0.0005839163,0.000601959,0.0004060477,0.003714613,0.005963536],"genre_scores_gemma":[0.7407223,0.001359393,0.2495172,0.0004375981,0.0001121062,0.0003683698,0.0003220344,0.00008887801,0.007072113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001296098,"threshold_uncertainty_score":0.003183782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01530572051260452,"score_gpt":0.2510545102503177,"score_spread":0.2357487897377132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}