{"id":"W4388072202","doi":"10.1136/jitc-2023-sitc2023.0594","title":"594 SQZ-PBMC-HPV-101: Increased overall survival in a subset of patients with recurrent, locally advanced, or metastatic HPV16<sup>+</sup>tumors treated with cell-based vaccine, SQZ-PBMC-HPV","year":2023,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Peripheral blood mononuclear cell; Medicine; Antigen; CD8; T cell; Immunotherapy; Immunology; Immune system; Internal medicine; Oncology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001948321,0.0001774574,0.00036703,0.0001291424,0.0001333588,0.0002512694,0.00009893191,0.0002186739,0.001429731],"category_scores_gemma":[0.0001840887,0.00008012712,0.0002314886,0.0001067967,0.0001466767,0.0001463844,0.0001282621,0.0002532945,0.0002423872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002017584,"about_ca_system_score_gemma":0.0001462347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002423717,"about_ca_topic_score_gemma":0.0004145591,"domain_scores_codex":[0.9999107,0.00002009094,0.00000609272,0.00002974214,0.00001320745,0.00002019074],"domain_scores_gemma":[0.9998817,0.00002526082,0.0000226248,0.000009757115,0.00001008991,0.00005047051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.04235015,0.001724952,0.7856842,0.0001414949,0.0002252033,0.001541146,0.0002233269,0.0009502576,0.1125384,0.0000707842,0.001317755,0.05323246],"study_design_scores_gemma":[0.0008693691,0.03841601,0.9425046,0.00001324518,0.000263489,0.003376452,0.0001697299,0.002103933,0.009771029,0.0000830299,0.002410314,0.00001875205],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994443,0.0001195426,0.00005851596,0.00001523441,0.000003961917,0.00000998133,0.0001030115,0.000003517986,0.0002418038],"genre_scores_gemma":[0.9994426,0.00004816662,0.00004756208,0.0000188064,0.000007419512,0.000009315948,0.000229862,0.000001029453,0.0001952157],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001429731,"threshold_uncertainty_score":0.004782975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01966662828364165,"score_gpt":0.2677507664605239,"score_spread":0.2480841381768823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}