{"id":"W4388073962","doi":"10.1016/j.cmet.2023.10.003","title":"Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and inflammation","year":2023,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":false,"ca_institutions":"Research Manitoba; Jewish General Hospital; McGill University; University of British Columbia","funders":"Fondation De Famille Alvin Segal; Warren Y. Soper Charitable Trust; Michael Smith Health Research BC; Canadian Institutes of Health Research; Genome Canada; University of British Columbia; McGill University; Lustgarten Foundation","keywords":"Hyperinsulinemia; Endocrinology; Pancreatic Intraepithelial Neoplasia; Internal medicine; Pancreatic cancer; Insulin; Pancreas; Biology; Hyperinsulinism; Cancer; Cancer research; Glucose homeostasis; Medicine; Insulin resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007731587,0.0002330231,0.0006107888,0.0003223263,0.0001816437,0.00002882066,0.00008316497,0.0001719222,0.0001172075],"category_scores_gemma":[0.001427651,0.0002038612,0.00004302038,0.0008337109,0.0001157611,0.0001850609,0.0001001094,0.0003099555,0.0002490063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001286445,"about_ca_system_score_gemma":0.0002086535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005622666,"about_ca_topic_score_gemma":0.00001841743,"domain_scores_codex":[0.9981304,0.0002260893,0.0003712283,0.0004597711,0.000353876,0.0004586555],"domain_scores_gemma":[0.9988162,0.0002086387,0.0001176967,0.0002717599,0.0002257593,0.0003599469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001478871,0.0001625026,0.1197965,0.00051268,0.0002174131,0.00005588377,0.006999778,0.00005963091,0.8196285,0.00004767549,0.005989057,0.04505154],"study_design_scores_gemma":[0.003237441,0.0004264783,0.6959234,0.0005207353,0.0009590076,0.00008639313,0.0009344459,0.001800098,0.2414526,0.000290715,0.05375877,0.0006098616],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924467,0.002543654,0.0001744571,0.001906992,0.0004400129,0.001030245,0.00001657675,0.0001664479,0.001274872],"genre_scores_gemma":[0.9889932,0.005317059,0.001232639,0.0002071163,0.0007398473,0.0002891764,0.00009157368,0.00004633537,0.003083084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5781758,"threshold_uncertainty_score":0.8313219,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02476799292950678,"score_gpt":0.3096720208867021,"score_spread":0.2849040279571953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}