{"id":"W4388073962","doi":"10.1016/j.cmet.2023.10.003","title":"Hyperinsulinemia acts via acinar insulin receptors to initiate pancreatic cancer by increasing digestive enzyme production and inflammation","year":2023,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":80,"is_retracted":false,"has_abstract":false,"ca_institutions":"Research Manitoba; Jewish General Hospital; McGill University; University of British Columbia","funders":"Fondation De Famille Alvin Segal; Warren Y. Soper Charitable Trust; Michael Smith Health Research BC; Canadian Institutes of Health Research; Genome Canada; University of British Columbia; McGill University; Lustgarten Foundation","keywords":"Hyperinsulinemia; Endocrinology; Pancreatic Intraepithelial Neoplasia; Internal medicine; Pancreatic cancer; Insulin; Pancreas; Biology; Hyperinsulinism; Cancer; Cancer research; Glucose homeostasis; Medicine; Insulin resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003243109,0.0004889999,0.0003161387,0.0005025575,0.0002681408,0.000911854,0.0001631424,0.0003831325,0.003353348],"category_scores_gemma":[0.0003018118,0.0002173798,0.0004958686,0.0003646398,0.0004214208,0.0005513837,0.0004005611,0.001075135,0.00034727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004844917,"about_ca_system_score_gemma":0.0002602462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003692533,"about_ca_topic_score_gemma":0.0005183509,"domain_scores_codex":[0.9997434,0.0000800815,0.00001985058,0.00004328675,0.00005825036,0.00005504262],"domain_scores_gemma":[0.9997236,0.00006113099,0.0000740912,0.0000375756,0.00003358127,0.00006988193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003730259,0.0002454338,0.01219777,0.0002215053,0.0001006059,0.000919971,0.000116218,0.0001528856,0.9677367,0.001065311,0.0003098201,0.01320349],"study_design_scores_gemma":[0.0002668213,0.003602081,0.1326866,0.0000465241,0.0001847787,0.002350354,0.0007785553,0.0007318418,0.844548,0.001530747,0.01323732,0.00003647719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9722787,0.01137759,0.005387809,0.001000187,0.0002681026,0.0001038687,0.0003478446,0.0001950553,0.009040815],"genre_scores_gemma":[0.9913806,0.00358963,0.001678253,0.000273914,0.00009577701,0.00003841516,0.0001716774,0.0000200252,0.002751711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003353348,"threshold_uncertainty_score":0.01121807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02476799292950678,"score_gpt":0.3096720208867021,"score_spread":0.2849040279571953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}