{"id":"W4388074720","doi":"10.1136/jitc-2023-sitc2023.1396","title":"1396 TriTCE CPI: a novel trispecifc T cell engager platform with integrated PD-1/PD-L1 checkpoint inhibition engineered for the treatment of immunosuppressed tumors","year":2023,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"Cancer research; Tumor microenvironment; PD-L1; T cell; Immunotherapy; Immune checkpoint; Cytotoxicity; Cytotoxic T cell; Immune system; Chemistry; Cancer immunotherapy; In vitro; Biology; Immunology; Tumor cells; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007235535,0.0003923426,0.000633489,0.0002808554,0.0001954644,0.0000729547,0.0001083138,0.0001934897,0.00007226085],"category_scores_gemma":[0.0002594388,0.0002456453,0.0002473367,0.0006302821,0.0003803669,0.0001397726,0.00002568432,0.0003532949,0.00001089985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000222967,"about_ca_system_score_gemma":0.0004515206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002979281,"about_ca_topic_score_gemma":0.00002767834,"domain_scores_codex":[0.99778,0.00004087994,0.0006060056,0.0004513068,0.0005723402,0.0005494628],"domain_scores_gemma":[0.998096,0.0004545457,0.000199464,0.0005638284,0.0002563425,0.0004298193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00228246,0.0005107818,0.0002835607,0.0003783926,0.0003822856,0.0001032148,0.002609957,0.0002955811,0.9904523,0.00009540874,0.001280466,0.001325547],"study_design_scores_gemma":[0.01067979,0.002250309,0.01932085,0.0003685351,0.0002780163,0.0001741289,0.001557403,0.002696514,0.9390438,0.00009742066,0.02322768,0.0003055782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947912,0.0007748984,0.0001828175,0.001232476,0.0001732709,0.002192474,0.0001531739,0.0001534639,0.0003462414],"genre_scores_gemma":[0.9929757,0.0006191132,0.0008548574,0.00006701159,0.0002360052,0.0003144202,0.000324919,0.00009750415,0.00451048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05140857,"threshold_uncertainty_score":0.9999996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.040494279708013,"score_gpt":0.2694589960541106,"score_spread":0.2289647163460976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}