{"id":"W4388074720","doi":"10.1136/jitc-2023-sitc2023.1396","title":"1396 TriTCE CPI: a novel trispecifc T cell engager platform with integrated PD-1/PD-L1 checkpoint inhibition engineered for the treatment of immunosuppressed tumors","year":2023,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"Cancer research; Tumor microenvironment; PD-L1; T cell; Immunotherapy; Immune checkpoint; Cytotoxicity; Cytotoxic T cell; Immune system; Chemistry; Cancer immunotherapy; In vitro; Biology; Immunology; Tumor cells; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000115266,0.0003313409,0.0001296245,0.0001952455,0.0000961157,0.000286499,0.0003170161,0.0004194661,0.002443615],"category_scores_gemma":[0.0001014232,0.0001323536,0.0001712125,0.0001477655,0.0001244949,0.0002096383,0.0002079918,0.0006331378,0.0008506285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002834969,"about_ca_system_score_gemma":0.000182885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003527417,"about_ca_topic_score_gemma":0.000585804,"domain_scores_codex":[0.9998668,0.00001286048,0.000008346103,0.00002739261,0.00005262359,0.00003197528],"domain_scores_gemma":[0.9999435,0.000005253763,0.00001867484,0.000005468179,0.0000101746,0.00001690408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001000403,0.0001098299,0.0001053918,0.00003774798,0.000007369437,0.00006455582,0.00001478705,0.0003917371,0.9935782,0.0003316975,0.0004467987,0.004811747],"study_design_scores_gemma":[0.00002453417,0.0006782977,0.0003811905,0.000002769853,0.000006621019,0.0001872573,0.000008190734,0.001980372,0.9928619,0.00003634091,0.003824581,0.000008050732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9647864,0.00139777,0.01917001,0.000249883,0.0001007979,0.0002376802,0.001005347,0.0005150784,0.01253717],"genre_scores_gemma":[0.9817939,0.0005203951,0.01023679,0.0001733786,0.00001459525,0.000130209,0.0007947025,0.00004423413,0.006291721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002443615,"threshold_uncertainty_score":0.008174717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.040494279708013,"score_gpt":0.2694589960541106,"score_spread":0.2289647163460976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}