{"id":"W4388075493","doi":"10.1002/ange.202315768","title":"Impact of the Core Chemistry of Self‐Assembled Spherical Nucleic Acids on their <i>In Vitro</i> Fate","year":2023,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Canada Foundation for Innovation","keywords":"Nucleic acid; Chemistry; Gene silencing; Oligonucleotide; Biophysics; Aptamer; RNA; Small molecule; In vitro; Biodistribution; Small interfering RNA; Cell biology; DNA; Biochemistry; Biology; Molecular biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004113043,0.000252891,0.0001215188,0.0001008087,0.0001454013,0.0004175133,0.0001699931,0.0001748745,0.0008490098],"category_scores_gemma":[0.0006347382,0.0001406836,0.0001039274,0.00007927619,0.0002228836,0.0002514739,0.0001271704,0.0002046222,0.0003224577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003910938,"about_ca_system_score_gemma":0.0002541978,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007898347,"about_ca_topic_score_gemma":0.0007668889,"domain_scores_codex":[0.9998287,0.00004448855,0.00001593069,0.00004195766,0.00003558959,0.00003326438],"domain_scores_gemma":[0.99962,0.0001464395,0.00009678637,0.00002805986,0.00007319095,0.00003559681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001090306,0.00001878785,0.0001490371,0.00003343849,0.000006469834,0.00002410791,0.0000320694,0.0003581434,0.9981872,0.0001548289,0.00003801021,0.0008889005],"study_design_scores_gemma":[0.000002246527,0.00007271487,0.0002438636,0.00000136452,0.000002741706,0.00000852938,0.000005940848,0.0008001104,0.9986014,0.00001082561,0.0002481197,0.000002074674],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950923,0.0004357386,0.001792321,0.00002810472,0.00001470243,0.00002398632,0.0001429005,0.00005891544,0.002411018],"genre_scores_gemma":[0.998566,0.0001484927,0.0006677277,0.00001276869,0.000002336299,0.00001081423,0.00008898137,0.00002421489,0.0004786791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008490098,"threshold_uncertainty_score":0.002840221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01432214717817228,"score_gpt":0.2769721889537787,"score_spread":0.2626500417756065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}