{"id":"W4388077918","doi":"10.1007/s11302-023-09975-6","title":"Preclinical evaluation of bozepinib in bladder cancer cell lines: modulation of the NPP1 enzyme","year":2023,"lang":"en","type":"article","venue":"Purinergic Signalling","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Natural Sciences and Engineering Research Council of Canada; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Purinergic receptor; Cisplatin; Cell culture; Extracellular; Adenosine; Cell cycle; Purinergic signalling; Apoptosis; Cell; Pharmacology; Cell growth; Cancer research; Biochemistry; Biology; Medicine; Internal medicine; Adenosine receptor; Receptor; Chemotherapy; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005515061,0.0008527511,0.0008558799,0.0004487438,0.0003958851,0.0007109278,0.0005876309,0.0007051498,0.003934478],"category_scores_gemma":[0.0003042946,0.0002833177,0.000617298,0.0003934719,0.0004219778,0.00039929,0.0002028339,0.002581603,0.0006877338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007740755,"about_ca_system_score_gemma":0.001334832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002133695,"about_ca_topic_score_gemma":0.007579225,"domain_scores_codex":[0.9997868,0.00005069659,0.00001213707,0.00002769286,0.00004212823,0.00008062092],"domain_scores_gemma":[0.9998474,0.00002582541,0.00002118081,0.00001632925,0.00002909372,0.00006014381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01671957,0.01074192,0.001552145,0.001365649,0.0004275703,0.0004728328,0.0002495204,0.005277976,0.9034602,0.001737934,0.006549735,0.0514449],"study_design_scores_gemma":[0.01096463,0.1136505,0.01381789,0.000143238,0.0006601163,0.0008874207,0.000378396,0.003414688,0.8123455,0.0006042341,0.0430399,0.00009342087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9733887,0.007712774,0.002718268,0.00121718,0.0004775252,0.001618143,0.004052691,0.0003178502,0.008496914],"genre_scores_gemma":[0.9793569,0.006268708,0.002274756,0.0004608951,0.0000475478,0.001231593,0.003935338,0.00003951106,0.006384893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003934478,"threshold_uncertainty_score":0.01316214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05333815461063588,"score_gpt":0.334008712879769,"score_spread":0.2806705582691331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}