{"id":"W4388077918","doi":"10.1007/s11302-023-09975-6","title":"Preclinical evaluation of bozepinib in bladder cancer cell lines: modulation of the NPP1 enzyme","year":2023,"lang":"en","type":"article","venue":"Purinergic Signalling","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Natural Sciences and Engineering Research Council of Canada; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Purinergic receptor; Cisplatin; Cell culture; Extracellular; Adenosine; Cell cycle; Purinergic signalling; Apoptosis; Cell; Pharmacology; Cell growth; Cancer research; Biochemistry; Biology; Medicine; Internal medicine; Adenosine receptor; Receptor; Chemotherapy; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001000167,0.0001290039,0.0001850132,0.00006046976,0.00003309407,0.000005224329,0.0002231671,0.0001421265,0.0001166807],"category_scores_gemma":[0.0001716495,0.0001032991,0.0001308011,0.0003458548,0.00004771562,0.000007215603,0.0001081581,0.00009384664,0.000002158999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001978202,"about_ca_system_score_gemma":0.0001673341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002065039,"about_ca_topic_score_gemma":0.00005199564,"domain_scores_codex":[0.9984279,0.0001718191,0.0005316046,0.000275577,0.00040308,0.0001900119],"domain_scores_gemma":[0.9991328,0.00006802138,0.0002549231,0.0002623234,0.000250452,0.00003146201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004273724,0.0000633212,0.007983541,0.00004238322,0.00003286722,3.926589e-7,0.0001155958,0.5209234,0.469267,0.00002043745,0.0008315255,0.0006767932],"study_design_scores_gemma":[0.001471951,0.00009946778,0.02655927,0.00013096,0.0001041122,0.000001264137,0.0001644278,0.2131445,0.7572159,0.0003743291,0.0005185219,0.0002153634],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933448,0.005239101,0.0002897681,0.0001002109,0.000187654,0.0002664054,0.00001034351,0.00000976727,0.0005519129],"genre_scores_gemma":[0.9985489,0.0005518811,0.00008183267,0.00003514221,0.0003136722,0.0000557771,0.00005206756,0.00002041651,0.0003403075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.307779,"threshold_uncertainty_score":0.4212416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05333815461063588,"score_gpt":0.334008712879769,"score_spread":0.2806705582691331,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}