{"id":"W4388078138","doi":"10.3390/curroncol30110696","title":"Preclinical Synergistic Combination Therapy of Lurbinectedin with Irinotecan and 5-Fluorouracil in Pancreatic Cancer","year":2023,"lang":"en","type":"article","venue":"Current Oncology","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Brown University","keywords":"Irinotecan; Pancreatic cancer; Medicine; Cancer research; Combination therapy; Cancer; Chemotherapy; Topoisomerase; Apoptosis; Oncology; Pharmacology; Internal medicine; Colorectal cancer; In vitro; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003579127,0.000458982,0.0005130045,0.0005102365,0.0002018051,0.0002851287,0.0004073989,0.0003194779,0.001702761],"category_scores_gemma":[0.0001126065,0.0002268132,0.0003381446,0.0003280972,0.0002499495,0.0003222506,0.0001756226,0.001053505,0.0002315734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005237176,"about_ca_system_score_gemma":0.0007298531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001160095,"about_ca_topic_score_gemma":0.002616221,"domain_scores_codex":[0.9998037,0.00005601317,0.00001432982,0.00002889687,0.00004580521,0.00005129936],"domain_scores_gemma":[0.9999344,0.00001126151,0.00001271309,0.000007898413,0.000005276899,0.0000283611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00457518,0.004583364,0.000519402,0.0003962754,0.00009960742,0.0002521139,0.00009954902,0.003147251,0.960007,0.0005218734,0.001042367,0.02475607],"study_design_scores_gemma":[0.001916522,0.05359926,0.004907104,0.00004769325,0.0002648474,0.000687779,0.0000659451,0.006063052,0.9180501,0.0001698849,0.01419886,0.00002893506],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851094,0.00569095,0.002248343,0.0003231441,0.0001577716,0.0005056396,0.0005511091,0.0001476305,0.005266063],"genre_scores_gemma":[0.9908631,0.003364052,0.002879761,0.00006873823,0.00002584571,0.0002156655,0.0004592855,0.00001548178,0.002108074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001702761,"threshold_uncertainty_score":0.005696297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.218484638062463,"score_gpt":0.4900962086634709,"score_spread":0.2716115706010079,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}