{"id":"W4388083448","doi":"10.1136/jitc-2023-sitc2023.1532","title":"1532 A phase 1/2 study of safety, tolerability, and pharmacokinetics of SNS-101, a pH-sensitive anti-VISTA mAb, as monotherapy and in combination with cemiplimab in patients with advanced solid tumors","year":2023,"lang":"en","type":"article","venue":"","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Tolerability; Pharmacokinetics; Phase (matter); Pharmacology; Computer science; Medicine; Chemistry; Adverse effect; Organic chemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001025901,0.001139089,0.00140186,0.0003883289,0.0003443504,0.0009133958,0.0006050374,0.0008526353,0.004349936],"category_scores_gemma":[0.0005811246,0.0004987314,0.0009664895,0.0003852252,0.0008084548,0.0007714259,0.0002104817,0.002794141,0.001128094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001022613,"about_ca_system_score_gemma":0.001788618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001089698,"about_ca_topic_score_gemma":0.002311799,"domain_scores_codex":[0.9995753,0.0001916835,0.00001721864,0.00008248771,0.00005596018,0.00007725355],"domain_scores_gemma":[0.9994156,0.00008932324,0.000126472,0.00006679661,0.00004906343,0.0002526415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.4245394,0.1589367,0.008931135,0.000625097,0.00105031,0.0005471359,0.0004096094,0.005478982,0.2686066,0.0004604269,0.009484183,0.1209305],"study_design_scores_gemma":[0.1270393,0.8242331,0.01519974,0.00002015479,0.0002853684,0.0005786533,0.00009096564,0.002570005,0.02450375,0.0002130605,0.005211005,0.00005499148],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926096,0.0007720705,0.000828451,0.0002380188,0.00008023292,0.001928234,0.001435586,0.0001088063,0.001999066],"genre_scores_gemma":[0.9854689,0.0008387755,0.003111608,0.0006752818,0.0001398927,0.002097918,0.003534409,0.00007827555,0.004054789],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004349936,"threshold_uncertainty_score":0.014552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007759437215717626,"score_gpt":0.3129283156724704,"score_spread":0.3051688784567528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}