{"id":"W4388083448","doi":"10.1136/jitc-2023-sitc2023.1532","title":"1532 A phase 1/2 study of safety, tolerability, and pharmacokinetics of SNS-101, a pH-sensitive anti-VISTA mAb, as monotherapy and in combination with cemiplimab in patients with advanced solid tumors","year":2023,"lang":"en","type":"article","venue":"","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Tolerability; Pharmacokinetics; Phase (matter); Pharmacology; Computer science; Medicine; Chemistry; Adverse effect; Organic chemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001002282,0.0001260008,0.0002506993,0.0001168051,0.00001948869,0.000007313592,0.00004470028,0.00002866436,0.00000439633],"category_scores_gemma":[0.00001323537,0.00009838604,0.00001114958,0.0002548356,0.00009627007,0.000008326855,0.00006580572,0.00005213146,1.445979e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002105301,"about_ca_system_score_gemma":0.00004992739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003743092,"about_ca_topic_score_gemma":0.0008022199,"domain_scores_codex":[0.9990819,0.00006034647,0.0002199397,0.0002922248,0.0001773433,0.0001683194],"domain_scores_gemma":[0.9996114,0.0000188509,0.00008140994,0.0001262786,0.0001121034,0.00004990314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0213051,0.007184104,0.8675339,0.0000931032,0.0002054779,0.000038186,0.001196258,0.0002967832,0.08922809,0.000009001217,0.000009202345,0.01290086],"study_design_scores_gemma":[0.06456211,0.01693702,0.7536581,0.00006967961,0.00001997657,0.000002590338,0.001126834,0.0003561951,0.1630415,0.00003612808,0.00001046557,0.0001794021],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988,0.00004292958,0.00001633304,0.00003140698,0.000004140456,0.0009763297,0.00004655212,0.000004322334,0.00007799859],"genre_scores_gemma":[0.9995859,0.0002013358,0.0000510338,0.00001421822,0.000002433182,0.00003254344,0.00008091048,0.00001359735,0.00001798449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1138757,"threshold_uncertainty_score":0.4012066,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007759437215717626,"score_gpt":0.3129283156724704,"score_spread":0.3051688784567528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}