{"id":"W4388083490","doi":"10.1136/jitc-2023-sitc2023.0783","title":"783 Combined immunotherapy improves outcome for replication repair deficient (RRD) high-grade glioma failing anti-PD1 monotherapy: a report from the International RRD consortium","year":2023,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Stand Up To Cancer","keywords":"Ipilimumab; Medicine; Nivolumab; Internal medicine; Immunotherapy; Progression-free survival; Oncology; Melanoma; Progressive disease; Chemotherapy; Cancer research; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001429046,0.0002979491,0.0003698288,0.0002634583,0.0002021622,0.0004980642,0.0002090084,0.0002210414,0.0004861724],"category_scores_gemma":[0.0008501646,0.0000552055,0.000495437,0.0003419968,0.0002489171,0.000193148,0.0002141796,0.000373283,0.0001475171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005186811,"about_ca_system_score_gemma":0.0006502614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001513752,"about_ca_topic_score_gemma":0.002210054,"domain_scores_codex":[0.9997236,0.00009339675,0.00003135436,0.00004726026,0.00005011712,0.00005417563],"domain_scores_gemma":[0.9995235,0.0001178332,0.0001126113,0.00007111047,0.00007987741,0.00009513435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.038491,0.004790933,0.4128561,0.0006719975,0.001940655,0.001708016,0.0005849936,0.001304216,0.05267624,0.000267419,0.009128533,0.4755799],"study_design_scores_gemma":[0.005572238,0.06495434,0.8721603,0.0001661556,0.002334627,0.00469842,0.0004729683,0.001832273,0.03098404,0.0002206472,0.01652865,0.00007538967],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924143,0.004298791,0.0002684298,0.0003781607,0.00002020481,0.00009139287,0.0004738016,0.00002867492,0.002026173],"genre_scores_gemma":[0.9963136,0.001615961,0.0004089843,0.0002999278,0.00004683944,0.00005611836,0.0009614501,0.000009528913,0.0002875328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001513752,"threshold_uncertainty_score":0.007557631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03118325356358788,"score_gpt":0.293107385921724,"score_spread":0.2619241323581362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}