{"id":"W4388084134","doi":"10.1136/jitc-2023-sitc2023.0741","title":"741 TWT-101: a first-in-clinic study of CFI-402411, a hematopoietic progenitor Kinase-1 (HPK1) inhibitor, as single agent or combined with pembrolizumab in subjects with advanced solid malignancies","year":2023,"lang":"en","type":"article","venue":"Regular and Young Investigator Award Abstracts","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Alberta; University Health Network; Ottawa Hospital","funders":"","keywords":"Pembrolizumab; Medicine; Internal medicine; Adverse effect; Gastroenterology; Oncology; Toxicity; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004839745,0.0004659804,0.0009473981,0.000434851,0.0001100058,0.00005603691,0.0001527822,0.0001740917,0.0000241899],"category_scores_gemma":[0.0002201505,0.0003323935,0.00009558148,0.001257473,0.0004273125,0.0001948259,0.00006052286,0.0002938455,0.00001313056],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002021519,"about_ca_system_score_gemma":0.0008141621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005618504,"about_ca_topic_score_gemma":0.00411617,"domain_scores_codex":[0.9969741,0.00009552891,0.0008907755,0.0006816132,0.0007198765,0.0006381055],"domain_scores_gemma":[0.9984592,0.0001237062,0.0003491777,0.0005358507,0.0001358193,0.0003962709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1041895,0.01077983,0.523491,0.006363291,0.001586139,0.01431519,0.03509759,0.0004032538,0.2999808,0.00004212102,0.001862515,0.001888803],"study_design_scores_gemma":[0.05087716,0.03043638,0.6716201,0.007364524,0.0004067325,0.001060815,0.01587049,0.00008961055,0.2199949,0.0001257913,0.00102754,0.001125887],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959788,0.0006132535,5.38552e-7,0.0006224492,0.0001917905,0.002280312,0.000009278482,0.0001293077,0.0001742928],"genre_scores_gemma":[0.9983832,0.0001570804,0.000161177,0.0001510096,0.00005990971,0.0002176879,0.00002505381,0.00008547368,0.0007594102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1481291,"threshold_uncertainty_score":0.9999128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02282469974766373,"score_gpt":0.2716791618740001,"score_spread":0.2488544621263364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}