{"id":"W4388084576","doi":"10.9778/cmajo.20220136","title":"Screening and testing practices for Lynch syndrome in Nova Scotians with endometrial cancer: a descriptive study","year":2023,"lang":"en","type":"article","venue":"CMAJ Open","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nova Scotia Health Authority; Izaak Walton Killam Health Centre; Dalhousie University","funders":"","keywords":"Lynch syndrome; Endometrial cancer; Medicine; Genetic testing; Population; Gynecology; Internal medicine; Cancer; Oncology; Germline mutation; Genetic counseling; Colorectal cancer; DNA mismatch repair; Mutation; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003539891,0.0001534355,0.0002301712,0.0008464984,0.001002425,0.0005011456,0.0004591286,0.0002770427,0.001415499],"category_scores_gemma":[0.001999975,0.0002725563,0.0002447932,0.001493856,0.0005034939,0.0001979353,0.0006503573,0.0002991662,0.00018789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003863473,"about_ca_system_score_gemma":0.004278586,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.7839819,"about_ca_topic_score_gemma":0.8229843,"domain_scores_codex":[0.9994628,0.00006551148,0.0000836028,0.00007960556,0.0001442697,0.0001641497],"domain_scores_gemma":[0.997933,0.0003088206,0.0007945845,0.00007535407,0.0004558372,0.0004323733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00001593886,0.00001138423,0.9980087,0.00002662809,0.000006734466,0.0001742496,0.0008677743,0.00001697243,0.0001006872,0.00001077722,0.0001413984,0.0006187026],"study_design_scores_gemma":[0.000002269081,0.00003167438,0.9969627,0.00003215134,0.000004937909,0.0002420872,0.002425777,0.00006921252,0.00002187928,0.000003643619,0.0002007239,0.000002895272],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981667,0.000173886,0.00002696393,0.00006746117,0.000003389885,0.0000312336,0.0008379377,0.000001577674,0.0006908884],"genre_scores_gemma":[0.9992024,0.0001888775,0.00004954464,0.00005207418,0.000002053789,0.00001503871,0.0003042735,9.613055e-7,0.000184835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2160181,"threshold_uncertainty_score":0.4345805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2354186646528314,"score_gpt":0.414554394780467,"score_spread":0.1791357301276356,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}