{"id":"W4388086360","doi":"10.1038/s12276-023-01106-w","title":"IRE1α protects against osteoarthritis by regulating progranulin-dependent XBP1 splicing and collagen homeostasis","year":2023,"lang":"en","type":"article","venue":"Experimental & Molecular Medicine","topic":"Fibromyalgia and Chronic Fatigue Syndrome Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Army Medical University; Chongqing Medical University; China Postdoctoral Science Foundation; York University; Chongqing Postdoctoral Science Foundation; Strong; National Natural Science Foundation of China","keywords":"Unfolded protein response; XBP1; Homeostasis; Cell biology; Cartilage; Osteoarthritis; Cancer research; Phosphorylation; Alternative splicing; RNA splicing; Medicine; Chemistry; Biology; Endoplasmic reticulum; Pathology; Messenger RNA; Biochemistry; Anatomy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004478721,0.0003557755,0.0005880137,0.0002762623,0.0002405874,0.00003823638,0.0001432205,0.0001564898,0.0002068106],"category_scores_gemma":[0.0001350843,0.000313477,0.00009195253,0.0006286742,0.0003993677,0.00008188273,0.0002095386,0.0002573928,0.00006991904],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002172508,"about_ca_system_score_gemma":0.0001113365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001217046,"about_ca_topic_score_gemma":0.000001173239,"domain_scores_codex":[0.9968449,0.0001167939,0.000467005,0.0006811358,0.001135346,0.0007547546],"domain_scores_gemma":[0.9988198,0.00005118435,0.00009908732,0.0004654941,0.0000773674,0.0004871129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001153555,0.00009276443,0.0001776114,0.0006020017,0.00008665679,0.001025356,0.001598199,0.000001823076,0.9793698,0.00003323211,0.002087126,0.01481005],"study_design_scores_gemma":[0.008003215,0.003386839,0.0006546843,0.002349366,0.00004610153,0.0004355459,0.005376155,0.000267608,0.9780455,0.00002800663,0.001038986,0.0003679599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9686287,0.02492451,0.00005978976,0.002277589,0.0001204076,0.002007997,0.00001208277,0.0002810225,0.001687863],"genre_scores_gemma":[0.9972619,0.0003295696,0.0004161719,0.0001452542,0.00007780659,0.000329343,0.0002785405,0.00009785608,0.001063504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02863322,"threshold_uncertainty_score":0.9999318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01609927645907956,"score_gpt":0.3087879968440083,"score_spread":0.2926887203849288,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}