{"id":"W4388092089","doi":"10.3390/curroncol30110697","title":"Anti-B Cell Maturation Antigen Chimeric Antigen Receptor T Cell Therapy for the Treatment of AL Amyloidosis and Concurrent Relapsed/Refractory Multiple Myeloma: Preliminary Efficacy and Safety","year":2023,"lang":"en","type":"article","venue":"Current Oncology","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Sanofi; Bristol-Myers Squibb; Pharmacyclics; Amgen","keywords":"Medicine; Chimeric antigen receptor; Multiple myeloma; Cytokine release syndrome; Amyloidosis; Refractory (planetary science); AL amyloidosis; Internal medicine; Oncology; Immunotherapy; Antibody; Immunology; Immunoglobulin light chain; Cancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004352626,0.000208695,0.0003506043,0.0001793319,0.0002983217,0.0004813856,0.0001142903,0.0003393259,0.0004796252],"category_scores_gemma":[0.0004895955,0.00005242161,0.0003337162,0.0001074587,0.0002882396,0.0001918825,0.0001836507,0.0007663016,0.0001673823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002684007,"about_ca_system_score_gemma":0.0002568967,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004147522,"about_ca_topic_score_gemma":0.001027361,"domain_scores_codex":[0.9998611,0.00004277639,0.00001516129,0.00001590678,0.0000273772,0.00003758658],"domain_scores_gemma":[0.9997373,0.00008741552,0.00003293452,0.00002830369,0.00002169047,0.00009232337],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.01702663,0.007397288,0.06048877,0.0005095039,0.0004384159,0.03398779,0.001183094,0.005045346,0.1667624,0.001661262,0.004662387,0.700837],"study_design_scores_gemma":[0.009113722,0.2111126,0.3477403,0.0002539375,0.001531125,0.1469071,0.0006723723,0.01905218,0.1885968,0.003156891,0.07172256,0.000140403],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859746,0.004535032,0.003421833,0.0009695222,0.00006285059,0.000157776,0.0001125879,0.00006198219,0.004703706],"genre_scores_gemma":[0.9972829,0.0009560771,0.0007412812,0.0002682086,0.00008352761,0.0000306777,0.0001240919,0.000009776219,0.0005035049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004813856,"threshold_uncertainty_score":0.002301931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0400138184344026,"score_gpt":0.3365546719460932,"score_spread":0.2965408535116906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}