{"id":"W4388115127","doi":"10.1016/s2352-3018(23)00233-3","title":"Integrase strand-transfer inhibitor use and cardiovascular events in adults with HIV: an emulation of target trials in the HIV-CAUSAL Collaboration and the Antiretroviral Therapy Cohort Collaboration","year":2023,"lang":"en","type":"article","venue":"The Lancet HIV","topic":"HIV-related health complications and treatments","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Hip and Knee Clinic; University of Calgary; McGill University Health Centre","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; National Institute on Alcohol Abuse and Alcoholism; European Regional Development Fund; Stichting HIV Monitoring; Center for AIDS Research, University of Washington; Alberta Innovates; ViiV Healthcare; Ministerie van Volksgezondheid, Welzijn en Sport; National Institutes of Health; U.S. Department of Veterans Affairs; Office of Research and Development; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Institut National de la Santé et de la Recherche Médicale; Instituto de Salud Carlos III; Bill and Melinda Gates Foundation; European Centre for Disease Prevention and Control; Deutsches Zentrum für Infektionsforschung; Wellcome Trust; Styrelsen för Internationellt Utvecklingssamarbete; Gilead Sciences; National Institute for Health and Care Research; Canadian Institutes of Health Research; National Science Foundation","keywords":"Medicine; Dolutegravir; Regimen; Observational study; Clinical trial; Logistic regression; Viral load; Integrase inhibitor; Internal medicine; Cohort; Human immunodeficiency virus (HIV); Antiretroviral therapy; Family medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.07250171,0.000693347,0.002897928,0.0008448754,0.0007220137,0.003842964,0.001212081,0.00293602,0.002537099],"category_scores_gemma":[0.1154387,0.0005592123,0.003714281,0.002496054,0.0010658,0.002637121,0.003039508,0.005070101,0.0002751878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001415428,"about_ca_system_score_gemma":0.003824159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005074162,"about_ca_topic_score_gemma":0.01217422,"domain_scores_codex":[0.9263057,0.0590481,0.005355176,0.002551562,0.00553309,0.001206429],"domain_scores_gemma":[0.8551687,0.1049479,0.01699525,0.008665971,0.00970131,0.004520751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.09213541,0.000995697,0.1948878,0.01890813,0.1259987,0.0002285364,0.00214628,0.002541852,0.001573925,0.02136045,0.1025198,0.4367035],"study_design_scores_gemma":[0.06717134,0.01183033,0.5229991,0.03370498,0.1459565,0.0007631899,0.00270731,0.004634938,0.002902789,0.042806,0.1637804,0.0007431582],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2477178,0.5810128,0.005445143,0.1204358,0.01187795,0.001130753,0.01049581,0.0001306932,0.02175313],"genre_scores_gemma":[0.813044,0.1285698,0.008347468,0.02887527,0.01341407,0.001045823,0.004074474,0.0001515892,0.002477505],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.07250171,"threshold_uncertainty_score":0.3834303,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03736909684616156,"score_gpt":0.3193847594316641,"score_spread":0.2820156625855025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}