{"id":"W4388124188","doi":"10.1200/jco.23.00914","title":"First-Line Pembrolizumab + Chemotherapy Versus Placebo + Chemotherapy for Persistent, Recurrent, or Metastatic Cervical Cancer: Final Overall Survival Results of KEYNOTE-826","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":236,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec; Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Medicine; Pembrolizumab; Hazard ratio; Clinical endpoint; Chemotherapy; Placebo; Internal medicine; Cervical cancer; Clinical trial; Surgery; Oncology; Confidence interval; Cancer; Immunotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007790854,0.001566525,0.003262673,0.000669206,0.0004759349,0.001601925,0.0007176002,0.001705648,0.006508378],"category_scores_gemma":[0.004519857,0.0004432402,0.005086707,0.0005087992,0.0006142181,0.00163936,0.0007371415,0.003954008,0.001261496],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009969547,"about_ca_system_score_gemma":0.001201825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005591018,"about_ca_topic_score_gemma":0.001520744,"domain_scores_codex":[0.9973214,0.0015709,0.0002353669,0.0003088109,0.0002844547,0.0002790132],"domain_scores_gemma":[0.9977418,0.0008118513,0.000530783,0.0002662507,0.0002332012,0.0004160466],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9274567,0.005899387,0.001648191,0.001633049,0.004025938,0.00003024866,0.00006116676,0.0008959002,0.003722534,0.0002526704,0.003501583,0.05087255],"study_design_scores_gemma":[0.493123,0.4541701,0.02636555,0.0005353256,0.008857001,0.0001768619,0.0001037197,0.001772347,0.005135669,0.0009305504,0.008760261,0.00006970627],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.917816,0.04002767,0.003206922,0.00176187,0.002131739,0.00821519,0.01031156,0.0004739695,0.01605494],"genre_scores_gemma":[0.9661937,0.005764246,0.003077776,0.001760477,0.0007510331,0.006661425,0.007485047,0.00008773832,0.008218352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007790854,"threshold_uncertainty_score":0.04120243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2622251498244805,"score_gpt":0.4862756760409937,"score_spread":0.2240505262165132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}