{"id":"W4388126090","doi":"10.1371/journal.pone.0293167","title":"Pangenomic antiviral effect of REP 2139 in CRISPR/Cas9 engineered cell lines expressing hepatitis B virus surface antigen","year":2023,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"HBsAg; Virology; Hepatitis B virus; Biology; Entecavir; Hepatocellular carcinoma; Virus; Lamivudine; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002228747,0.0003119534,0.0004102951,0.0001657958,0.000129263,0.000365821,0.0003074132,0.0004970265,0.001668441],"category_scores_gemma":[0.0001973372,0.0001626336,0.0002857407,0.0001095104,0.0002018413,0.0002215733,0.0001886188,0.000627099,0.0003589229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001744063,"about_ca_system_score_gemma":0.0001755807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006193892,"about_ca_topic_score_gemma":0.0008729767,"domain_scores_codex":[0.9997723,0.0000278629,0.00004113262,0.0000528867,0.00007150842,0.00003437031],"domain_scores_gemma":[0.9998844,0.00002908503,0.00003190754,0.00001933239,0.00001331221,0.00002185347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001494569,0.00005177373,0.0001493147,0.0001042221,0.000009561381,0.00009560929,0.00002386779,0.0001862237,0.997047,0.000150224,0.0001240663,0.001908753],"study_design_scores_gemma":[0.00003005311,0.0005630629,0.001345751,0.000009202635,0.00003382824,0.0002388178,0.0000281245,0.002172221,0.9917666,0.0000462126,0.0037535,0.00001262083],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9836105,0.001178434,0.008793962,0.0001548617,0.0001473378,0.0000949249,0.00136489,0.0004801086,0.004174906],"genre_scores_gemma":[0.9879403,0.0005967259,0.006382145,0.00009475049,0.000009814861,0.00009665752,0.001045072,0.00005140046,0.003783218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001668441,"threshold_uncertainty_score":0.005581558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03920343900564117,"score_gpt":0.2683442491330078,"score_spread":0.2291408101273666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}