{"id":"W4388127276","doi":"10.1182/hem.v20.6.2023610","title":"Bitopertin for Erythropoietic Protoporphyria: A New Paradigm — and New Hope — for a Rare, Devastating Disease","year":2023,"lang":"en","type":"article","venue":"The Hematologist","topic":"Porphyrin Metabolism and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"","keywords":"Erythropoietic protoporphyria; Disease; Rare disease; Medicine; Biology; Pathology; Protoporphyrin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002304122,0.00017224,0.000201144,0.00002928261,0.0002157599,0.00005096924,0.0002068522,0.00007136745,0.000006664887],"category_scores_gemma":[0.0006737475,0.0001192452,0.0001119018,0.0001205661,0.0001540174,0.000005226708,0.000113052,0.00004355119,0.00001081903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002760343,"about_ca_system_score_gemma":0.0002136187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006512825,"about_ca_topic_score_gemma":0.00003245453,"domain_scores_codex":[0.9989633,0.00003382711,0.0002121011,0.0003547915,0.00007676274,0.0003592118],"domain_scores_gemma":[0.9992724,0.00008232429,0.00009152432,0.0003409257,0.00002604781,0.0001867583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003744863,0.0002386043,0.009261766,0.001409837,0.0003588001,0.00003482451,0.0009783371,0.0002761503,0.04604267,0.05295371,0.8419532,0.04274723],"study_design_scores_gemma":[0.009875845,0.0007026628,0.006349503,0.0001339568,0.0003749625,0.000116002,0.001179268,0.002211239,0.03662807,0.1546558,0.7864552,0.001317457],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8291224,0.01849241,0.1075252,0.03318723,0.0007410562,0.009982829,0.0002917211,0.00028618,0.0003709281],"genre_scores_gemma":[0.9764721,0.0009300088,0.009748798,0.002125556,0.0008811593,0.002255464,0.0005535615,0.0001128541,0.006920434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1473497,"threshold_uncertainty_score":0.4862679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03919671843531331,"score_gpt":0.301002005367592,"score_spread":0.2618052869322787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}