{"id":"W4388127519","doi":"10.1016/j.celrep.2023.113336","title":"Impaired gut microbiota-mediated short-chain fatty acid production precedes morbidity and mortality in people with HIV","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Janssen Pharmaceuticals; ZonMw; National Institute of Allergy and Infectious Diseases; Cedars-Sinai Medical Center; Crohn's and Colitis Foundation; ViiV Healthcare; National Institutes of Health; Aids Fonds; Gilead Sciences","keywords":"Microbiome; Butyrate; Comorbidity; Inflammation; Short-chain fatty acid; Human immunodeficiency virus (HIV); Immunology; Population; Gut flora; Feces; Medicine; Biology; Physiology; Internal medicine; Bioinformatics; Microbiology; Environmental health; Food science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001792363,0.000197255,0.0002063782,0.0003012033,0.0003200892,0.0005586857,0.0001732738,0.0003094524,0.002233093],"category_scores_gemma":[0.001100577,0.0001691507,0.000158448,0.0003664471,0.0001809282,0.0002981244,0.0004554568,0.0006730558,0.0001949982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001405578,"about_ca_system_score_gemma":0.0002501648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002664346,"about_ca_topic_score_gemma":0.004513078,"domain_scores_codex":[0.9998648,0.00002851229,0.000009948705,0.00003478452,0.00002747565,0.00003442369],"domain_scores_gemma":[0.9995241,0.00005904282,0.0002252088,0.00002762927,0.00005425168,0.0001098029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005098436,0.00007518686,0.9806668,0.00006123765,0.00005438159,0.0002465847,0.0001655927,0.00004691937,0.005456075,0.00006914633,0.0002670822,0.01238113],"study_design_scores_gemma":[0.000002203487,0.0001095089,0.998435,0.000018603,0.00001775526,0.0002666586,0.0001784788,0.00008062363,0.0006331385,0.0000669303,0.0001885773,0.000002583788],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970801,0.001522055,0.0001815765,0.0001000504,0.00002173127,0.00000884407,0.0003584454,0.000007375761,0.0007196513],"genre_scores_gemma":[0.9985258,0.0006030731,0.0001464779,0.00005170983,0.00001863202,0.000008082216,0.0002791512,0.000001956575,0.0003650813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002664346,"threshold_uncertainty_score":0.007470429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01485207573482515,"score_gpt":0.2549166508904261,"score_spread":0.240064575155601,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}