{"id":"W4388133835","doi":"10.1080/15548627.2023.2276639","title":"CKLF induces microglial activation via triggering defective mitophagy and mitochondrial dysfunction","year":2023,"lang":"en","type":"article","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"Mitophagy; PINK1; Cell biology; Autophagy; Biology; Microglia; Neuroinflammation; Lysosome; Parkin; Autophagosome; Mitochondrion; Proinflammatory cytokine; Inflammation; Immunology; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001192391,0.0002293116,0.0003218476,0.0002842726,0.0001937285,0.00004050862,0.00006670296,0.0002048596,0.0001578787],"category_scores_gemma":[0.0001172383,0.0002138581,0.0001137712,0.0005818121,0.00008313036,0.0002447226,0.00005116384,0.0002335321,0.0002146047],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009071638,"about_ca_system_score_gemma":0.0001026902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007694262,"about_ca_topic_score_gemma":0.000002667711,"domain_scores_codex":[0.9986069,0.0000630176,0.0002667286,0.0004397661,0.000277727,0.00034583],"domain_scores_gemma":[0.9992455,0.0001323742,0.000103553,0.0002494975,0.000100218,0.000168811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007166839,0.0001225608,0.0003232831,0.00006282818,0.0002111303,0.0001164827,0.0006659418,0.000009170095,0.9435547,0.0001734522,0.0009392391,0.05310451],"study_design_scores_gemma":[0.004544977,0.0004592062,0.1101159,0.00007401223,0.0001238204,0.00009000346,0.0001665733,0.0006713458,0.8786806,0.001593294,0.003202899,0.0002773453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959236,0.0003540415,0.0006872606,0.0002592011,0.001139963,0.0005199246,0.000008941334,0.0004520171,0.000654989],"genre_scores_gemma":[0.9965177,0.0001244261,0.0001881467,0.0003783226,0.001191837,0.00008600162,0.00007982915,0.00004623952,0.001387537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1097926,"threshold_uncertainty_score":0.8720883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01435922575395224,"score_gpt":0.2699593656808882,"score_spread":0.255600139926936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}