{"id":"W4388133835","doi":"10.1080/15548627.2023.2276639","title":"CKLF induces microglial activation via triggering defective mitophagy and mitochondrial dysfunction","year":2023,"lang":"en","type":"article","venue":"Autophagy","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Key Research and Development Program of China; National Natural Science Foundation of China","keywords":"Mitophagy; PINK1; Cell biology; Autophagy; Biology; Microglia; Neuroinflammation; Lysosome; Parkin; Autophagosome; Mitochondrion; Proinflammatory cytokine; Inflammation; Immunology; Biochemistry; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000163085,0.0005687982,0.0003481191,0.0003515936,0.0002366842,0.0002065587,0.0001585613,0.0005003242,0.0006951738],"category_scores_gemma":[0.0001239447,0.0001258506,0.0003630655,0.0001222303,0.000295914,0.0002883248,0.0002506406,0.0005484879,0.0001358103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004116342,"about_ca_system_score_gemma":0.0002146201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004764091,"about_ca_topic_score_gemma":0.0008414966,"domain_scores_codex":[0.9998181,0.00003143673,0.00001797327,0.00002195287,0.00003871552,0.00007181317],"domain_scores_gemma":[0.9999061,0.0000102681,0.00004041229,0.000008241627,0.00001095679,0.0000240178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005067546,0.00007876564,0.0002347631,0.0001149895,0.00001033402,0.0002345622,0.00002084653,0.00006031982,0.9971252,0.00007357109,0.00004701657,0.001492907],"study_design_scores_gemma":[0.0000804281,0.001264036,0.007275039,0.00001927315,0.00003983986,0.001064285,0.00006150661,0.0009976042,0.9874974,0.0001234899,0.001562969,0.00001419254],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938987,0.003396753,0.00144792,0.0001422695,0.00003506344,0.00004790548,0.0001258495,0.00006364785,0.0008418063],"genre_scores_gemma":[0.9972077,0.0009621377,0.0009140289,0.00005923351,0.00001897846,0.00005514145,0.0001305986,0.000006437752,0.0006455795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006951738,"threshold_uncertainty_score":0.00298661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01435922575395224,"score_gpt":0.2699593656808882,"score_spread":0.255600139926936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}