{"id":"W4388140204","doi":"10.3390/kinasesphosphatases1040017","title":"CK2 Chemical Probes: Past, Present, and Future","year":2023,"lang":"en","type":"article","venue":"Kinases and Phosphatases","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Canada Foundation for Innovation; North Carolina General Assembly; Pfizer; Bayer; U.S. Department of Defense","keywords":"Casein kinase 2; Allosteric regulation; Computational biology; Chemical biology; Drug discovery; In vivo; Kinase; Chemistry; Small molecule; Biology; Biochemistry; Protein kinase A; Enzyme; Biotechnology; Mitogen-activated protein kinase kinase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00213526,0.0006648727,0.0004864197,0.0006458369,0.0004081869,0.001688209,0.0006741164,0.001457855,0.004067253],"category_scores_gemma":[0.001014782,0.0004034266,0.0003664374,0.0005122254,0.00114344,0.003050833,0.0009014639,0.001904732,0.001409662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000989196,"about_ca_system_score_gemma":0.000878789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005629814,"about_ca_topic_score_gemma":0.00158831,"domain_scores_codex":[0.9996783,0.00008453184,0.00001999011,0.00006101743,0.00009322797,0.00006302557],"domain_scores_gemma":[0.999514,0.0002078183,0.00006476571,0.00002598501,0.0001042198,0.00008318581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005473336,0.0003616321,0.0009878526,0.004308981,0.00006234633,0.0007030122,0.0003977479,0.00181075,0.08785897,0.06153532,0.025686,0.8157399],"study_design_scores_gemma":[0.00007313699,0.001254143,0.0009930617,0.0008292421,0.00006998075,0.001471733,0.0003235024,0.00150811,0.03936782,0.01775273,0.9362809,0.00007569227],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01127081,0.9498641,0.01018586,0.009960239,0.0007400342,0.00005300404,0.0001498051,0.0001684556,0.01760777],"genre_scores_gemma":[0.0744836,0.8939838,0.01441256,0.004865395,0.0009604092,0.0001763912,0.0002370015,0.00007098453,0.01080979],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004067253,"threshold_uncertainty_score":0.01360631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009589535266676021,"score_gpt":0.2441374623217778,"score_spread":0.2345479270551018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}