{"id":"W4388140204","doi":"10.3390/kinasesphosphatases1040017","title":"CK2 Chemical Probes: Past, Present, and Future","year":2023,"lang":"en","type":"article","venue":"Kinases and Phosphatases","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Canada Foundation for Innovation; North Carolina General Assembly; Pfizer; Bayer; U.S. Department of Defense","keywords":"Casein kinase 2; Allosteric regulation; Computational biology; Chemical biology; Drug discovery; In vivo; Kinase; Chemistry; Small molecule; Biology; Biochemistry; Protein kinase A; Enzyme; Biotechnology; Mitogen-activated protein kinase kinase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007997842,0.0001342716,0.0001087551,0.00003055845,0.00009925595,0.00004295407,0.00006021713,0.00009094433,0.00003039431],"category_scores_gemma":[0.00001375239,0.0001173704,0.00003703449,0.0001084213,0.0000872314,0.000006109995,0.000130654,0.0000457789,0.00000662362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002345729,"about_ca_system_score_gemma":0.00001611463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001374677,"about_ca_topic_score_gemma":0.000001463481,"domain_scores_codex":[0.9992757,0.00002091651,0.0001163041,0.0003008707,0.00009047401,0.0001956654],"domain_scores_gemma":[0.9996428,0.00001411037,0.00003767029,0.0001660603,0.00002690482,0.0001124524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005336624,0.0002177966,0.01174623,0.0005440329,0.0001816613,0.0001324938,0.0002228884,0.0000428014,0.4316046,0.00479315,0.3166907,0.23329],"study_design_scores_gemma":[0.0004471409,0.00009549767,0.002482592,0.00002529821,0.00001715902,0.00002725173,0.0001009769,0.0001055746,0.3798684,0.0003045696,0.6163334,0.0001921955],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9732092,0.02430329,0.00004806362,0.001552366,0.0001000937,0.0002830157,0.0002380389,0.00006319014,0.0002027176],"genre_scores_gemma":[0.9918683,0.003367482,0.0003014524,0.000306919,0.002418665,0.00005881357,0.001311184,0.0000254415,0.000341773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2996427,"threshold_uncertainty_score":0.4786227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009589535266676021,"score_gpt":0.2441374623217778,"score_spread":0.2345479270551018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}