{"id":"W4388153112","doi":"10.1016/j.omto.2023.100743","title":"Improved oncolytic activity of a reovirus mutant that displays enhanced virus spread due to reduced cell attachment","year":2023,"lang":"en","type":"article","venue":"Molecular Therapy — Oncolytics","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Li Ka Shing Institute of Virology, University of Alberta; National Institutes of Health; Canada Research Chairs; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Cancer Research Society; Cure Brain Cancer Foundation; Emory University; University of Alberta; Faculty of Medicine and Dentistry, University of Alberta; Cancer Research Institute","keywords":"Oncolytic virus; Virus; Mutant; Cancer cell; Biology; Infectivity; Potency; Virology; Cancer; Cell culture; Cancer research; Myxoma virus; In vitro; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001465172,0.0003789812,0.0002223012,0.0001769293,0.00008806025,0.0002853421,0.0001789611,0.0003598484,0.0005443235],"category_scores_gemma":[0.0001352114,0.0001042668,0.0003051967,0.0001231437,0.0001940064,0.000182625,0.0001198105,0.0005540171,0.0001480879],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002581339,"about_ca_system_score_gemma":0.0002120198,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001362027,"about_ca_topic_score_gemma":0.001005025,"domain_scores_codex":[0.9998934,0.00001529883,0.00001321826,0.00002117439,0.00002806275,0.00002883432],"domain_scores_gemma":[0.9999061,0.00002338226,0.00002808977,0.00001305456,0.000009712567,0.00001969934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003901038,0.0000114235,0.00003711461,0.000007234145,0.000002109589,0.00001363477,0.000004167282,0.00008746002,0.9994538,0.00005592356,0.000007861603,0.0002802697],"study_design_scores_gemma":[0.000005805922,0.0001649956,0.0003925581,0.000001657361,0.000007275468,0.00008803128,0.000004153399,0.0007713392,0.9981487,0.0000120629,0.0004007527,0.000002758408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996146,0.0003244056,0.00278608,0.00003065799,0.0000169628,0.00001449175,0.0001259742,0.00004684558,0.0005085411],"genre_scores_gemma":[0.9957956,0.0002072496,0.002887846,0.00001586726,0.00000252837,0.000009500491,0.000196875,0.0000292677,0.000855262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001362027,"threshold_uncertainty_score":0.002708197,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02595720556413787,"score_gpt":0.3273071999934433,"score_spread":0.3013499944293054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}