{"id":"W4388153112","doi":"10.1016/j.omto.2023.100743","title":"Improved oncolytic activity of a reovirus mutant that displays enhanced virus spread due to reduced cell attachment","year":2023,"lang":"en","type":"article","venue":"Molecular Therapy — Oncolytics","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Li Ka Shing Institute of Virology, University of Alberta; National Institutes of Health; Canada Research Chairs; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Cancer Research Society; Cure Brain Cancer Foundation; Emory University; University of Alberta; Faculty of Medicine and Dentistry, University of Alberta; Cancer Research Institute","keywords":"Oncolytic virus; Virus; Mutant; Cancer cell; Biology; Infectivity; Potency; Virology; Cancer; Cell culture; Cancer research; Myxoma virus; In vitro; Gene; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007782028,0.0005532086,0.0006442817,0.0002786013,0.0001529685,0.00006315116,0.0008446134,0.0003716034,0.00005587247],"category_scores_gemma":[0.00009052116,0.0005481184,0.0003860571,0.000870057,0.0001363345,0.00001169569,0.0003683822,0.0003219325,0.0001113702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002621399,"about_ca_system_score_gemma":0.0005529749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001153628,"about_ca_topic_score_gemma":0.000185351,"domain_scores_codex":[0.9963887,0.0003375243,0.0005040197,0.001017089,0.0007670473,0.0009856495],"domain_scores_gemma":[0.9974075,0.00007062004,0.0002763416,0.001610724,0.0002276338,0.0004072086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00630446,0.0005836567,0.00002156898,0.0000551464,0.0002338324,0.00009499739,0.0002693109,0.0007647143,0.9726554,0.000004908244,0.0003551103,0.01865686],"study_design_scores_gemma":[0.002652384,0.007880163,0.0001951025,0.00004008316,0.00003401204,0.000009378041,0.00007159128,0.0007778758,0.984439,0.00004383305,0.00326969,0.0005869151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910203,0.0004597958,0.005168342,0.0004158278,0.0002574499,0.001804938,0.0001380322,0.00008623261,0.0006491052],"genre_scores_gemma":[0.9959523,0.0009531539,0.0004776425,0.0006696091,0.000146974,0.0003125512,0.0001053202,0.0001704734,0.001211993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01806995,"threshold_uncertainty_score":0.999697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02595720556413787,"score_gpt":0.3273071999934433,"score_spread":0.3013499944293054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}