{"id":"W4388182309","doi":"10.1016/j.euo.2023.10.004","title":"Olaparib plus Abiraterone for Metastatic Castration-resistant Prostate Cancer: Pharmacokinetics Data from the PROpel Trial","year":2023,"lang":"en","type":"article","venue":"European Urology Oncology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Olaparib; Abiraterone; Medicine; Prostate cancer; Pharmacokinetics; Pharmacology; Oncology; Internal medicine; Drug; Abiraterone acetate; Urology; Cancer; Androgen deprivation therapy; Androgen receptor; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001520134,0.000254994,0.0005341714,0.00009103907,0.0002303807,0.00003088731,0.0005911305,0.00007523633,0.0004140481],"category_scores_gemma":[0.0002849035,0.0001829156,0.00007838289,0.0003003578,0.0004211543,0.00008724944,0.0002337667,0.0004148203,0.0004634015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001674087,"about_ca_system_score_gemma":0.0008119801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001056642,"about_ca_topic_score_gemma":0.0002416648,"domain_scores_codex":[0.9967939,0.001061878,0.0006845297,0.000709271,0.0002201188,0.0005302975],"domain_scores_gemma":[0.9975259,0.0009330596,0.0003300682,0.0009138873,0.0001618754,0.0001351562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.2040436,0.0006622451,0.0003556669,0.0001017011,0.001502353,0.0012165,0.003034857,0.001189517,0.1124944,0.0002798775,0.6476668,0.02745249],"study_design_scores_gemma":[0.1197566,0.004453168,0.003010431,0.00002097431,0.0008455878,0.00006055018,0.0001733627,0.004487287,0.0007644435,0.000246681,0.8659479,0.0002330405],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8697729,0.002832131,0.001374359,0.09894741,0.00638792,0.009078934,0.005593343,0.0006686499,0.005344326],"genre_scores_gemma":[0.9565493,0.001849506,0.002362451,0.02292787,0.00507402,0.001320032,0.005420948,0.0002453308,0.004250569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2182811,"threshold_uncertainty_score":0.7459081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2073497634074418,"score_gpt":0.4296062803691044,"score_spread":0.2222565169616626,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}