{"id":"W4388182695","doi":"10.1101/2023.10.26.563876","title":"Intermittent Nicotine Access is as Effective as Continuous Access in Promoting Nicotine Seeking and Taking in Rats","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Nicotine; Self-administration; Addiction; Pharmacology; Nicotine Addiction; Medicine; Drug; Alkaloid; Drug intoxication; Smoking cessation; Psychology; Anesthesia; Internal medicine; Psychiatry; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003396057,0.0006259176,0.0007267358,0.000871391,0.0002859514,0.0005292519,0.0007468236,0.0007300524,0.002581066],"category_scores_gemma":[0.0003960533,0.0005126218,0.0007621999,0.0002754821,0.0009965712,0.0007120157,0.0005409002,0.002112549,0.0004812725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004364783,"about_ca_system_score_gemma":0.0004976692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001636914,"about_ca_topic_score_gemma":0.003281278,"domain_scores_codex":[0.9994634,0.00006722452,0.00004915382,0.0001546426,0.0001191873,0.0001463554],"domain_scores_gemma":[0.9988844,0.0001039847,0.0003109051,0.0001912242,0.0000676918,0.0004418891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004851647,0.002868842,0.0008628605,0.00008430539,0.00003294643,0.0001074872,0.0001350403,0.00008976941,0.9846146,0.0001524596,0.0001393243,0.00606065],"study_design_scores_gemma":[0.0006514157,0.05464116,0.03096159,0.00006896709,0.000186774,0.0004401222,0.000373111,0.002553284,0.9063687,0.0003619773,0.003301109,0.00009179459],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981244,0.0002834765,0.0006255043,0.0001062008,0.0000365079,0.00003560782,0.0002305775,0.0001127238,0.0004449183],"genre_scores_gemma":[0.9910363,0.0006963257,0.002988755,0.0001380947,0.00004967413,0.0002121512,0.0004572839,0.00006273713,0.004358634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002581066,"threshold_uncertainty_score":0.008634508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01733702639954433,"score_gpt":0.2954556338237755,"score_spread":0.2781186074242312,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}