{"id":"W4388182722","doi":"10.1101/2023.10.27.564451","title":"The proteomic toolbox for identification, quantification, and characterization of polyclonal antibodies","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Respiratory viral infections research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; University of Alberta","keywords":"Polyclonal antibodies; Antibody; Monoclonal antibody; Antibody Repertoire; Biology; Proteomics; Monoclonal; Isotype; Molecular biology; Chemistry; Virology; Immunology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003476164,0.001463826,0.001358132,0.003244885,0.0004637827,0.001614772,0.001006529,0.0007900542,0.004040038],"category_scores_gemma":[0.002283051,0.0008541506,0.0009717853,0.0009925611,0.0005608264,0.001553445,0.001782486,0.002078983,0.005690853],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005203608,"about_ca_system_score_gemma":0.0008077483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002547739,"about_ca_topic_score_gemma":0.0002810541,"domain_scores_codex":[0.9983588,0.000345599,0.0001418334,0.0004141015,0.0006557397,0.00008392227],"domain_scores_gemma":[0.9985784,0.0003682507,0.0001510631,0.0002996811,0.0004738472,0.000128674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001619124,0.00005104327,0.001317354,0.0006486652,0.0001180581,0.000164749,0.00007239486,0.0008230091,0.9095485,0.002902329,0.00399392,0.08019809],"study_design_scores_gemma":[0.00009695577,0.0003293426,0.007225398,0.0003154468,0.0001583454,0.00163545,0.0001379958,0.03169594,0.7917761,0.01576926,0.1507111,0.0001487336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.04386474,0.01064135,0.9137895,0.001293382,0.0003904816,0.0003515727,0.007091931,0.01524691,0.007330162],"genre_scores_gemma":[0.1192993,0.01131459,0.8448516,0.001067994,0.0003299271,0.001209694,0.01394714,0.00188073,0.00609913],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.004040038,"threshold_uncertainty_score":0.01838392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04758429250147922,"score_gpt":0.3149173576256471,"score_spread":0.2673330651241679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}