{"id":"W4388185443","doi":"10.1101/2023.10.25.564012","title":"Length-dependent Intramolecular Coil-to-Globule Transition in Poly(ADP-ribose) Induced by Cations","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Brookhaven National Laboratory; Basic Energy Sciences; National Institute of General Medical Sciences; Biological and Environmental Research; Natural Sciences and Engineering Research Council of Canada; Empire State Development Corporation; U.S. Department of Energy; Division of Materials Research; Office of Science; National Institutes of Health; National Science Foundation","keywords":"Small-angle X-ray scattering; Intramolecular force; Stacking; Molecular dynamics; Persistence length; Chemistry; Crystallography; Random coil; Bond length; Biophysics; Stereochemistry; Scattering; Molecule; Computational chemistry; Circular dichroism; Physics; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007968478,0.0002558866,0.0001673656,0.00009125951,0.0001434206,0.0002189814,0.0001393152,0.0001559199,0.003390438],"category_scores_gemma":[0.0001490116,0.00009597676,0.0001276721,0.0001254857,0.0001417598,0.000199249,0.0001496957,0.0003948851,0.0003522164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002003467,"about_ca_system_score_gemma":0.0001288345,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003725514,"about_ca_topic_score_gemma":0.0004524081,"domain_scores_codex":[0.9999471,0.000005713323,0.000002236397,0.00001569935,0.00001554022,0.00001371342],"domain_scores_gemma":[0.9999458,0.00001306279,0.00001884034,0.00000467366,0.000007137335,0.0000105487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004403306,0.00006997133,0.001684836,0.0002817038,0.00005261889,0.0002151898,0.00008797949,0.01134373,0.9744092,0.001461429,0.002123815,0.007829115],"study_design_scores_gemma":[0.0000737052,0.0003066719,0.010851,0.00002624916,0.00004068176,0.0001103968,0.00008220622,0.08678079,0.8934115,0.001781664,0.006487323,0.00004778894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845523,0.001120254,0.009219091,0.0004637851,0.0001402004,0.00003251095,0.001087336,0.0004485192,0.002935946],"genre_scores_gemma":[0.9954953,0.0005456255,0.001679969,0.0000684989,0.00001248913,0.00001886467,0.0004674887,0.00002607918,0.001685588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003390438,"threshold_uncertainty_score":0.01134211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02523055875533674,"score_gpt":0.2712541168102026,"score_spread":0.2460235580548658,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}